RecruitingPhase 1NCT07232589
A Study of the Effect of Diltiazem on the Plasma Levels of Nemtabrutinib (MK-1026-022)
A Study to Evaluate the Effect of Multiple Oral Doses of Diltiazem on the Single-Dose Pharmacokinetics of Nemtabrutinib in Healthy Participants.
Sponsor
Merck Sharp & Dohme LLC
Enrollment
24 participants
Start Date
Dec 8, 2025
Study Type
INTERVENTIONAL
Conditions
Summary
The goal of the study is to learn what happens to levels of nemtabrutinib (MK-1026) in a healthy person's body over time. Researchers will compare what happens to nemtabrutinib in the body when it is given with or without another medicine called diltiazem.
Eligibility
Min Age: 18 YearsMax Age: 55 Years
Inclusion Criteria2
- Be in good health
- BMI between 18.5 and 32 kg/m2, inclusive
Exclusion Criteria2
- History of clinically significant endocrine, gastrointestinal, cardiovascular, hematological (history of a bleeding disorder, abnormal bleeding or a hereditary or acquired coagulation or platelet disorder), hepatic, immunological, renal, respiratory, genitourinary, or major neurological (including stroke, intercranial hemorrhage, and chronic seizures) abnormalities or diseases
- History of cancer (malignancy)
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Interventions
DRUGNemtabrutinib
Oral administration
DRUGDiltiazem
Oral administration
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07232589
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