Generation of Endometrial Carcinoma Organoids
Feasibility Study of the Generation of Endometrial Carcinoma Organoids From Tumor Samples Transferred From Extramural Facilities
Regina Elena Cancer Institute
20 participants
Mar 23, 2025
OBSERVATIONAL
Conditions
Summary
A prospective pilot genetic study to evaluate the feasibility of generating organoids from endometrial tumor tissue collected during surgery, performed according to standard clinical practice. Samples will be collected from collaborating extramural facilities, with the aim of analyzing the impact of transport on tissue viability and the success of organoid culture. This study is for exploratory purposes only, without altering the diagnostic and therapeutic pathways of the participants.
Eligibility
Inclusion Criteria3
- Age \>18 years;
- Patients with a histological diagnosis of: endometrial cancer, endometrioid histology, any stage of disease (FIGO I-IV), recurrence/metastasis from endometrial endometrioid cancer, and candidates for surgery and/or hysterectomy;
- Written informed consent (study participation and data processing) must be obtained in person and/or through a legal representative/guardian/support administrator/witness, before any study-specific procedure is performed.
Exclusion Criteria5
- Comorbidities not controlled with adequate medical therapy;
- Endometrial cavity infections (pyometra);
- Synchronous tumors;
- Neoadjuvant treatments;
- Previous radiation treatments to the pelvic region.
Interventions
Creation of endometrial carcinoma organoids from tumor tissue from extramural structures, verifying the feasibility of organoid generation. Evaluate the impact of sample transport and storage conditions on the success of the process, considering the challenges associated with preserving tissue integrity.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07258186