RecruitingPhase 2NCT07306624

Nelmastobart in Combination With Docetaxel in Non Small Cell Lung Cancer

A Multicenter, Phase 2 Clinical Trial Based on an Adaptive Design to Evaluate the Safety and Efficacy of Nelmastobart in Combination With Docetaxel in Patients With Advanced/Metastatic Non-Small Cell Lung Cancer Who Are Resistant or Intolerant to Platinum-based Chemotherapy and/or Immunotherapy


Sponsor

STCube, Inc.

Enrollment

62 participants

Start Date

Jan 10, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

A Multicenter, Phase 2 Clinical Trial Based on an Adaptive Design to Evaluate the Safety and Efficacy of Nelmastobart in Combination with Docetaxel in Patients with Advanced/Metastatic Non-Small Cell Lung Cancer Who Are Resistant or Intolerant to Platinum-based Chemotherapy and/or Immunotherapy


Eligibility

Min Age: 19 Years

Plain Language Summary

Simplified for easier understanding

This study tests a drug called nelmastobart in combination with docetaxel (standard chemotherapy) for people with advanced non-small cell lung cancer (NSCLC) whose cancer has progressed after previous treatments. **You may be eligible if...** - You have been confirmed to have stage IIIb, IIIc, or IV non-squamous non-small cell lung cancer (NSCLC) that has returned or worsened - Your tumor tests positive for a protein called BTN1A1 (TPS score ≥50) - You have previously received appropriate treatments based on your tumor's genetic makeup and PD-1/PD-L1 therapy - You have adequate physical functioning (ECOG performance status) **You may NOT be eligible if...** - Your tumor does not meet the BTN1A1 positivity threshold - You have not received required prior therapies - You have poor overall health or organ function Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGNelmastobart and Docetaxel

Nelmastobart 800mg and Docetaxel 75mg/m2


Locations(5)

The Catholic University of Korea St. Vincent's Hospital

Gyeonggi-do, South Korea

Kangbuk Samsung Hospital

Seoul, South Korea

Korea University Anam Hospital

Seoul, South Korea

Samsung Medical Center

Seoul, South Korea

Seoul National University Bundang Hospital

Seoul, South Korea

View Full Details on ClinicalTrials.gov

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NCT07306624


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