RecruitingPhase 2NCT07321873

A Study to Evaluate the Efficacy and Safety of JNJ-88545223 for the Treatment of Participants With Active Psoriatic Arthritis

A Phase 2b, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging Study to Evaluate the Efficacy and Safety of JNJ-88545223 For the Treatment of Participants With Active Psoriatic Arthritis

Sponsor

Janssen Research & Development, LLC

Enrollment

240 participants

Start Date

Jan 15, 2026

Study Type

INTERVENTIONAL

Conditions

Arthritis, Psoriatic

Summary

The purpose of this study is to evaluate how well the study drug JNJ-88545223 works compared with a placebo (an inactive substance) in adults with active psoriatic arthritis (PsA). The study aims to see whether treatment with JNJ-88545223 can help reduce the signs and symptoms of PsA and improve joint and skin health.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called JNJ-88545223 and a drug called Placebo for people with arthritis, psoriatic. The study is currently recruiting participants at 68 locations. People eligible for this study include aged 18 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGJNJ-88545223

JNJ-88545223 will be administered.

DRUGPlacebo

Placebo will be administered.

Locations(68)

Unity Health-White County Medical Center

Searcy, Arkansas, United States

Newport Huntington Medical Group

Huntington Beach, California, United States

Rheumatology Center of San Diego

San Diego, California, United States

American Research, LLC

Cutler Bay, Florida, United States

Innovation Medical Research Center

Palmetto Bay, Florida, United States

Integral Rheumatology And Immunology Specialists

Plantation, Florida, United States

Clinical Research of West Florida

Tampa, Florida, United States

Conquest Research

Winter Park, Florida, United States

Atlanta Research Center for Rheumatology

Marietta, Georgia, United States

Willow Rheumatology and Wellness PLLC

Willowbrook, Illinois, United States

Qualmedica Research

Evansville, Indiana, United States

Albuquerque Rehabilitation and Rheumatology

Albuquerque, New Mexico, United States

Joint and Muscle Research Institute

Charlotte, North Carolina, United States

Paramount Medical Research & Consulting

Middleburg Heights, Ohio, United States

Clinical Research Philadelphia

Philadelphia, Pennsylvania, United States

Arthritis and Rheumatology Research Institute

Allen, Texas, United States

Peking University People's Hospital

Beijing, China

Peking University Third Hospital

Beijing, China

Xiangya Hospital Central South University

Changsha, China

Changzhou No 2 Peoples Hospital

Changzhou, China

West China Hospital Sichuan University

Chengdu, China

The First Affiliated Hospital of Chongqing Medical University

Chongqing, China

The Second Affiliated Hospital of Zhejiang University

Hangzhou, China

Ningbo medical center lihuili hospital

Ningbo, China

RHEUMA s r o

Břeclav, Czechia

L K N Arthrocentrum

Hlučín, Czechia

Revmatologicka ambulance

Karvina Frystat, Czechia

Pratia Czech A S

Pardubice, Czechia

Clintrial s r o

Prague, Czechia

Medical Plus Research S R O

Uherské Hradiště, Czechia

Fachklinik Bad Bentheim

Bad Bentheim, Germany

Charite Universitaetsmedizin Berlin

Berlin, Germany

Rheumatologische Schwerpunktpraxis

Berlin, Germany

Hamburger Rheuma Forschungszentrum II

Hamburg, Germany

CAIR Heidelberg

Heidelberg, Germany

Gemeinschaftspraxis Dres. Quist

Mainz, Germany

Hautarztpraxis Mortazawi

Remscheid, Germany

Hautarztpraxis

Witten, Germany

Semmelweis Egyetem Reumatologiai es Immunologiai Klinika

Budapest, Hungary

Obudai Egeszsegugyi Centrum Kft

Budapest, Hungary

Qualiclinic Kft

Budapest, Hungary

Porcika Klinika - Vasarhelyi Sarkanyfu Kft.

Hódmezővásárhely, Hungary

Complex Rendelo Med Zrt

Székesfehérvár, Hungary

Tokyo Metropolitan Tama Medical Center

Fuchū, Japan

Imamura General Hospital

Kagoshima, Japan

Hospital of the University of Occupational and Environmental Health

Kitakyushu-shi, Japan

Osaka Metropolitan University Hospital

Osaka, Japan

Sanuki Municipal Hospital

Sanuki, Japan

Tokito Clinic Rheumatology and Orthopaedic Surgery

Shimonoseki, Japan

Nzoz Osteo Medic

Bialystok, Poland

Szpital Uniwersytecki nr 2 im dr Jana Biziela w Bydgoszczy

Bydgoszcz, Poland

Centrum Kliniczno Badawcze

Elblag, Poland

Malopolskie Badania Kliniczne Sp z o o

Krakow, Poland

Pratia MCM Krakow

Krakow, Poland

ETG Lublin

Lublin, Poland

NZOZ Lecznica MAK MED S C

Nadarzyn, Poland

Etyka Osrodek Badan Klinicznych Tomasz Pesta S K A

Olsztyn, Poland

MICS Centrum Medyczne Torun

Torun, Poland

MICS Centrum Medyczne Warszawa

Warsaw, Poland

MICS Centrum Medyczne Warszawa 1

Warsaw, Poland

Rheuma Medicus Sp z o o

Warsaw, Poland

Centrum Medyczne Reuma Park

Warsaw, Poland

FutureMeds Targowek

Warsaw, Poland

Hosp Univ A Coruna

A Coruña, Spain

Hosp. Clinico Univ. de Santiago

Santiago de Compostela, Spain

Hosp. Virgen Macarena

Seville, Spain

Hosp. Infanta Luisa

Seville, Spain

Hosp. Virgen Del Rocio

Seville, Spain

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NCT07321873

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