A Study Of Moderately Hypo-Fractionated External-beam Radiotherapy With Concurrent Chemotherapy and High Dose Rate Brachytherapy In Cervical Cancer

This study is testing whether delivering radiation in fewer but slightly larger daily doses (moderately hypofractionated radiotherapy) combined with chemotherapy and internal radiation (brachytherapy) is as effective and safe as the standard radiation schedule for women with locally advanced cervical cancer. **You may be eligible if...** - You are 18 or older - You have confirmed cervical cancer (squamous cell, adenocarcinoma, or adenosquamous), at FIGO stages IB1–IIB, IIIA, IIIB, or selected IIIC1 cases - You are a candidate for definitive chemoradiotherapy (combined chemotherapy and radiation as your primary treatment) - You can receive weekly cisplatin or carboplatin chemotherapy - You are suitable for internal radiation (brachytherapy) - You are in adequate physical condition (ECOG 0–2) **You may NOT be eligible if...** - Your cancer is stage IA, IIIC2, IVA, or IVB - You have had previous pelvic or abdominal radiation - You have active inflammatory bowel disease or a connective tissue disorder (e.g., lupus, scleroderma) - You cannot have an MRI scan Talk to your doctor to see if this trial is right for you.