RecruitingPhase 2NCT07364786

Effect of Salovum® on Pressure, Oxygen and Inflammation in Glioblastoma

Intratumoral Pressure, Intratumoral Partial Oxygen Pressure, and Inflammatory Cytokines in Antisecretory Factor Treatment of Glioblastoma


Sponsor

Peter Siesjö

Enrollment

10 participants

Start Date

Oct 7, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The objective of this clinical trial is to investigate the effects of Salovum®, an egg yolk powder enriched with the endogenous protein antisecretory factor, in participants undergoing diagnostic biopsies for suspected glioblastoma. The primary questions the trial seeks to answer are: * Will Salovum® reduce intratumoral pressure? * Will Salovum® influence the release of inflammatory cytokines from tumor tissue? Additionally, the study will investigate the impact of Salovum® on intratumoral partial oxygen pressure and tumor volume. Researchers will: * Place probes for measuring intratumoral pressure, microdialysis, and partial oxygen pressure during a standard biopsy procedure. * Compare measurements from participants before and during ingestion of Salovum®. Participants will: * Have probes implanted during a surgical biopsy. * Ingest Salovum® 24 to 72 hours after the procedure.


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Inclusion Criteria4

  • Suspected glioblastoma
  • Age 18-75 years
  • Planned diagnostic biopsy
  • Informed consent of subject

Exclusion Criteria1

  • \. Known egg yolk allergy

Interventions

DIETARY_SUPPLEMENTSalovum

Ingestion of Salovum 11g three times daily during 48 hours


Locations(1)

Department of Neurosurgery, Skane University Hospital

Lund, Sweden

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NCT07364786


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