Effect of Salovum® on Pressure, Oxygen and Inflammation in Glioblastoma
Intratumoral Pressure, Intratumoral Partial Oxygen Pressure, and Inflammatory Cytokines in Antisecretory Factor Treatment of Glioblastoma
Peter Siesjö
10 participants
Oct 7, 2024
INTERVENTIONAL
Conditions
Summary
The objective of this clinical trial is to investigate the effects of Salovum®, an egg yolk powder enriched with the endogenous protein antisecretory factor, in participants undergoing diagnostic biopsies for suspected glioblastoma. The primary questions the trial seeks to answer are: * Will Salovum® reduce intratumoral pressure? * Will Salovum® influence the release of inflammatory cytokines from tumor tissue? Additionally, the study will investigate the impact of Salovum® on intratumoral partial oxygen pressure and tumor volume. Researchers will: * Place probes for measuring intratumoral pressure, microdialysis, and partial oxygen pressure during a standard biopsy procedure. * Compare measurements from participants before and during ingestion of Salovum®. Participants will: * Have probes implanted during a surgical biopsy. * Ingest Salovum® 24 to 72 hours after the procedure.
Eligibility
Inclusion Criteria4
- Suspected glioblastoma
- Age 18-75 years
- Planned diagnostic biopsy
- Informed consent of subject
Exclusion Criteria1
- \. Known egg yolk allergy
Interventions
Ingestion of Salovum 11g three times daily during 48 hours
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07364786