Prevalence of Airway Closure
Annual Prevalence of Airway Closure During the Full Support Phase of Invasive Mechanical Ventilation in Adults in an Intensive Care Unit
Romina Belen Mattei
75 participants
Sep 1, 2025
OBSERVATIONAL
Conditions
Summary
The primary objective of this study is to describe the prevalence of airway closure during the total support phase of invasive mechanical ventilation in subjects admitted to an intensive care unit (ICU). The secondary objective is to analyze whether there are clinical-demographic and/or ventilatory characteristics associated with the presence of airway closure.
Eligibility
Inclusion Criteria4
- Patients over 18 years of age
- Requiring invasive mechanical ventilation within 48 to 72 hours after orotracheal intubation
- Hemodynamically stable (mean arterial pressure greater than 60 mmHg and/or norepinephrine less than 0.5 mcg/kg/min)
- Without respiratory muscle effort
Exclusion Criteria3
- Neumothorax
- Bronchopleural fistula
- Clinical evidence or suspicion of elevated intracranial pressure (greater than 18 mmHg)
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Interventions
After setting the flow at 5 L/min and positive end-expiratory pressure (PEEP) at 0 cmH2O, the respiratory rate will be transiently decreased to achieve a prolonged expiration of 5-10 seconds to eliminate auto-PEEP. During two breaths, the change in the slope of the pressure-time curve will be observed. Airway Closure be detected as a change in the slope of the pressure-time curve. Airway Opening Pressure value, in cmH2O, will be identified on the pressure-volume curve using the cursor while the mechanical ventilator screen is frozen. Upon completion of this procedure, the ventilator settings will be returned to the patient's initial parameters.
Locations(1)
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NCT07368491