Glycocalyx and Oxidative Stress in Endothelial Function (Part 1)
The Role of Glycocalyx and Oxidative Stress in Endothelial Function (Part 1)
Josip Juraj Strossmayer University of Osijek
105 participants
Oct 1, 2025
OBSERVATIONAL
Conditions
Summary
The primary research objective of the project is to determine the role of eGC in microvascular reactivity in CKD (cross-sectional study 1). The main objective of the project is to increase the excellence and interdisciplinarity of scientific work at MEFOS by connecting researchers from different scientific fields, improving conditions and resources for scientific work, and increasing international cooperation, in line with strategic objective 1: raising scientific excellence. The results of the project could provide pathophysiological insight into the development and maintenance of endothelial dysfunction in CKD, as well as identify new biomarkers for CKD.
Eligibility
Inclusion Criteria3
- patients with CKD of hypertensive etiology (grades 1-2 and 3-5; eGFR CKD-EPI GFR ≥ 90 ml/min/1.73 m², i.e. \< 60 mL/min/1.73 m2), non-diabetics, non-smokers
- patients with hypertension (according to ESH2023 Guidelines) without kidney damage (eGFR CKD-EPI \>90 mL/min/1.73 m2) non-diabetics, non-smokers
- healthy volunteer subjects as controls
Exclusion Criteria4
- kidney disease of any other etiology except hypertension
- endocrine, autoimmune or inflammatory diseases that could affect kidney function.
- smoking
- diabetes
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07437729