Early Phase 1 AD Clinical Trials
157 recruitingEarly Phase 1
What is a Early Phase 1 trial?
Early Phase 1 trials are the earliest stage of testing in humans. These small studies focus on how a drug is processed in the body and how it affects the body, often enrolling just a handful of participants to establish initial safety data.
Showing 1–20 of 157 trials
Recruiting
Early Phase 1
Efficacy, Safety, and Pharmacokinetics of ThisCART19A Combined With Olverembatinib in Patients With Newly Diagnosed Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia.
Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia
The First Affiliated Hospital of Soochow University20 enrolled2 locationsNCT07074496
Recruiting
Early Phase 1
64Cu-LLP2A for Imaging Hematologic Malignancies
Chronic Lymphocytic LeukemiaMultiple MyelomaFollicular Lymphoma+4 more
Washington University School of Medicine42 enrolled1 locationNCT06636175
Recruiting
Early Phase 1
Dosimetry, Safety, and Efficacy Study of [177Lu]Lu-XT771 in Patients With Recurrent Glioblastoma
Recurrent Glioblastoma, IDH-WildtypeGlioblastoma (GBM)Recurrent Glioblastoma+1 more
Beijing Tiantan Hospital5 enrolled2 locationsNCT07648823
Recruiting
Early Phase 1
Addictive Threshold of Nicotine
smoking addiction
Yale University45 enrolled1 locationNCT06096714
Recruiting
Early Phase 1
First-in-human Diagnostic Imaging Profile of the Theranostic Pair [68Ga]Ga-DOTA-STR-17126 and Low Dose [177Lu] Lu-DOTA-STR-17126 in Patients With Advanced or Metastatic Cancer
Metastatic Breast CancerCancerMetastatic Prostate Cancer+5 more
Integrated Haematology and Oncology Network20 enrolled1 locationNCT07608848
Recruiting
Early Phase 1
Evaluation of [¹⁸F]MODAG-009 PET Imaging in Synucleinopathies
Parkinson DiseaseHealthy AdultMultiple System Atrophy (MSA)
MODAG GmbH13 enrolled1 locationNCT07640555
Recruiting
Early Phase 1
Feasibility Study on the Effect of a Methionine-Reduced Diet on Serum Levels in Pts w/ Solid Tumors
transitional cell carcinomaSoft Tissue SarcomaMelanoma+12 more
University of California, Irvine25 enrolled1 locationNCT07628634
Recruiting
Early Phase 1
Evaluation of the Pharmacokinetics, Biodistribution and Radiation Dosimetry of [18F]MODAG-009 Positron Emission Tomography (PET) Radiotracers in Adult Healthy Volunteers
Healthy Adult
MODAG GmbH6 enrolled1 locationNCT07617688
Recruiting
Early Phase 1
An Experimental Medicine Multicenter Trial to Evaluate the Safety and Immunogenicity of Experimental Versus Authorized SARS-CoV-2 Vaccine Candidates as a Booster Dose in Healthy Participants Previously Vaccinated With Authorized mRNA SARS-CoV-2 Vaccines.
Healthy Adults
ANRS, Emerging Infectious Diseases48 enrolled3 locationsNCT07605520
Recruiting
Early Phase 1
Multiparametic Metabolic and Hypoxic PET/MRI for Disease Assessment in High Grade Glioma
High Grade Glioma
University of Alabama at Birmingham20 enrolled2 locationsNCT05632562
Recruiting
Early Phase 1
Brain Mechanisms Supporting Cannabis-induced Pain Relief
Chronic Low Back Pain (CLBP)SciaticaLumbar Radiculopathy+4 more
University of California, San Diego100 enrolled1 locationNCT04982965
Recruiting
Early Phase 1
Evaluate the Safety and Efficacy of Subcutaneous Siplizumab in the Treatment of Hidradenitis Suppurativa.
Hidradenitis Suppurativa
University of Alabama at Birmingham12 enrolled1 locationNCT06326476
Recruiting
Early Phase 1
FET PET/CT Imaging To Localize Pituitary Adenomas In Cushing Disease
Pituitary AdenomaCushing Disease
Mayo Clinic50 enrolled1 locationNCT07460232
Recruiting
Early Phase 1
Prospective Screening for Pancreatic Ductal Adenocarcinoma in High-Risk Individuals
Pancreatic CancerPancreatic Ductal AdenocarcinomaPDAC+2 more
Dana-Farber Cancer Institute5,000 enrolled2 locationsNCT06122896
Recruiting
Early Phase 1
CDH17 CAR-T Therapy in Advanced Malignant Solid Tumors
Biliary Tract CancerColorectal CarcinomaGastric Cancer, Metastatic+2 more
Zhejiang University36 enrolled1 locationNCT06937567
Recruiting
Early Phase 1
Study of CBL0137 in Combination With Ipilimumab and Nivolumab Therapy in Melanoma
Locally Advanced or Metastatic Melanoma
Fox Chase Cancer Center12 enrolled1 locationNCT05498792
Recruiting
Early Phase 1
Active Surveillance and Chemotherapy Before Surgery in Treating Participants With Stage II-III Rectal Cancer
Rectal AdenocarcinomaStage II Rectal Cancer AJCC v8Stage III Rectal Cancer AJCC v8+6 more
M.D. Anderson Cancer Center120 enrolled1 locationNCT03594630
Recruiting
Early Phase 1
AMT-676 in Patients With Advanced Solid Tumors
Advanced Solid Tumors
Multitude Therapeutics Inc.24 enrolled13 locationsNCT06400485
Recruiting
Early Phase 1
A Phase I Study on Evaluating the Safety, Tolerability, Pharmacokinetic Characteristics and Preliminary Efficacy of SXRN Plasmid DNA Technique in Patients With Advanced Solid Tumors
Advanced CancerCachexia
Jiangsu Nutai Biologics Co., Ltd28 enrolled1 locationNCT06736275
Recruiting
Early Phase 1
A IIT Study of 177Lu-DOTA-SNA040
Advanced Solid Tumors (Such as Gastric Cancer)Advanced Solid Tumors (Such as Adenocarcinoma at the Gastroesophageal Junction)Advanced Solid Tumors (Such as Pancreatic Cancer)+1 more
SmartNuclide Biopharma12 enrolled1 locationNCT07595237