Advanced Gastrointestinal Stromal Tumor Clinical Trials

4 recruitingLast updated: June 18, 2026

There are 4 actively recruiting advanced gastrointestinal stromal tumor clinical trials across 29 countries. Studies span Phase 2, Phase 3. Top locations include Saint-Herblain, France, Villejuif, France, Marseille, France. Updated daily from ClinicalTrials.gov.


Advanced Gastrointestinal Stromal Tumor Trials at a Glance

4 actively recruiting trials for advanced gastrointestinal stromal tumor are listed on ClinicalTrialsFinder across 6 cities in 29 countries. The largest study group is Phase 2 with 3 trials, with the heaviest enrollment activity in Saint-Herblain, Villejuif, and Marseille. Lead sponsors running advanced gastrointestinal stromal tumor studies include Centre Leon Berard, Cogent Biosciences, Inc., and Merck Sharp & Dohme LLC.

Browse advanced gastrointestinal stromal tumor trials by phase

Treatments under study

About Advanced Gastrointestinal Stromal Tumor Clinical Trials

Looking for clinical trials for Advanced Gastrointestinal Stromal Tumor? There are currently 1 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Advanced Gastrointestinal Stromal Tumor trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Advanced Gastrointestinal Stromal Tumor clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 14 of 4 trials

Recruiting
Phase 3

(Peak) A Phase 3 Randomized Trial of CGT9486+Sunitinib vs. Sunitinib in Subjects With Gastrointestinal Stromal Tumors

Metastatic CancerAdvanced Gastrointestinal Stromal Tumors
Cogent Biosciences, Inc.482 enrolled126 locationsNCT05208047
Recruiting
Phase 2

Belzutifan/MK-6482 for the Treatment of Advanced Pheochromocytoma/Paraganglioma (PPGL), Pancreatic Neuroendocrine Tumor (pNET), Von Hippel-Lindau (VHL) Disease-Associated Tumors, Advanced Gastrointestinal Stromal Tumor (wt GIST), or Solid Tumors With HIF-2α Related Genetic Alterations (MK-6482-015)

Pancreatic Neuroendocrine TumorVon Hippel-Lindau DiseasePheochromocytoma/Paraganglioma+2 more
Merck Sharp & Dohme LLC355 enrolled84 locationsNCT04924075
Recruiting
Phase 2

A Prospective, Randomized, Multicenter, Comparative Study of the Efficacy of Imatinib Resumption Combined With Atezolizumab Versus Imatinib Resumption Alone in Patients With Unresectable Advanced Gastrointestinal Stromal Tumors (GIST) After Failure of Standard Treatments

Unresectable Gastrointestinal Stromal Tumor (GIST)Locally Advanced Gastrointestinal Stromal Tumor (GIST)Metastatic Gastrointestinal Stromal Tumor
Centre Leon Berard110 enrolled13 locationsNCT05152472
Recruiting
Phase 2

Efficiency of Imatinib Treatment After 10 Years of Treatment in Patients With Gastrointestinal Stromal Tumours (GIST) (Gist-Ten)

C-KIT MutationMetastatic Gastrointestinal Stromal Tumor (GIST)Advanced Gastrointestinal Stromal Tumor (GIST)
Centre Leon Berard50 enrolled13 locationsNCT05009927