Phase 1 BIA Clinical Trials
15 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–15 of 15 trials
Recruiting
Phase 1
Influence of Prosthetic Foot Stiffness on Transtibial Osseointegrated Bone-Anchored Limb Outcomes
AmputationTranstibial Amputation - UnilateralBone Anchored Devices
University of Colorado, Denver60 enrolled1 locationNCT07263945
Recruiting
Phase 1Phase 2
A Clinical Trial of EHT102 Injection in Pediatric Patients With Biallelic hOTOF Mutations
Treatment of Congenital Hearing Loss Secondary to Biallelic Mutations of the Otoferlin Gene (OTOF)
Shanghai Euhearing Therapeutics Co., Ltd30 enrolled1 locationNCT07288580
Recruiting
Phase 1Phase 2
A Study of DB-OTO, an Adeno-Associated Virus (AAV) Based Gene Therapy, in Children/Infants With Hearing Loss Due to Otoferlin Mutations
Congenital Hearing Loss Secondary to Biallelic Mutations of the Otoferlin Gene (OTOF)
Regeneron Pharmaceuticals30 enrolled15 locationsNCT05788536
Recruiting
Phase 1
Genicular Nerve Block After Open Reduction Internal Fixation of Tibial Plateau
Tibial Plateau Fractures
University of Chicago38 enrolled1 locationNCT06639503
Recruiting
Phase 1Phase 2
Safety and Preliminary Efficacy of VG801 in Patients With ABCA4 Mutation-associated Retinal Dystrophy (Stargardt Disease)
Retinal Dystrophy Due to Biallelic ABCA4 MutationsStargardt Disease 1
VeonGen Therapeutics GmbH15 enrolled1 locationNCT07002398
Recruiting
Phase 1
A Phase 1 Study of the Safety and Tolerability of Single and Multiple Ascending Doses of BWC0977 in Healthy Volunteers
Infectious DiseasesAntimicrobial Drug Resistance
Bugworks Research Inc.48 enrolled1 locationNCT07029932
Not Yet Recruiting
Phase 1
A Phase-I, randomised controlled trial (RCT) of Ultraviolet C (UVC) light therapy to assess ocular surface safety
Microbial keratitis
The University of Auckland22 enrolled1 locationACTRN12625001173482
Recruiting
Phase 1
Comparing Single Versus Repeat NMT on the Diversity of the Neonatal Nasal Microbiome
Staphylococcus AureusMicrobial ColonizationNeonatal Infection
Johns Hopkins University175 enrolled1 locationNCT06283355
Recruiting
Phase 1
Administering NMT to Reestablish Infant Nasal Microbiome Diversity Following Intranasal Mupirocin Treatment
Microbial ColonizationStaphylococcal Aureus InfectionPediatric Infection+2 more
Johns Hopkins University175 enrolled1 locationNCT06805994
Recruiting
Phase 1
Restoration of the Gut Microbiome After Cesarean Section
Microbial Colonization
Professor Klaus Bønnelykke80 enrolled2 locationsNCT06264219
Recruiting
Phase 1Phase 2
Gene Therapy in Subjects With Biallelic RPE65 Mutation-associated Retinal Dystrophy
Biallelic RPE65 Mutation-associated Retinal Dystrophy
Frontera Therapeutics9 enrolled1 locationNCT05858983
Completed
Phase 1
A Single Ascending Doses (SAD) of a Novel Engineered Cationic Peptide PLG0206 in Healthy Subjects.
Microbial Infections
Peptilogics, Inc.56 enrolled1 locationACTRN12618001920280
Withdrawn
Phase 1
A single centre, double blind, randomised, parallel group, single dose signal study of R-107 in participants with DSM-5 specific phobia
Specific phobia to spiders
Douglas Pharmaceuticals Ltd12 enrolled1 locationACTRN12618001381279
Completed
Phase 1
A Phase 1 Single-Center, Open-Label Study to Evaluate the Safety and Pharmacokinetics of a Candidate Topical Antimicrobial (NEO101) among Healthy Adult Men
Open-label safety pharmacokinetic study in healthy adult men of topical antimicrobial being developed for the indication of nasal carriage of Staphylococcus aureus.
Neosil, Inc5 enrolled1 locationACTRN12607000260426
Not Yet Recruiting
Phase 1
A safety study of autologous mesenchymal precursor cells (MPCs) in the management of delayed healing tibial fractures requiring secondary surgical intervention to promote fracture union.
Delayed or non-union tibial fracture
Mesoblast10 enrolled1 locationACTRN12605000051640