Clinical High Risk Clinical Trials

11 recruitingLast updated: June 20, 2026

There are 11 actively recruiting clinical high risk clinical trials across 5 countries. Studies span Not Applicable, Phase 1, Phase 2. Top locations include New York, New York, United States, Pittsburgh, Pennsylvania, United States, Chapel Hill, North Carolina, United States. Updated daily from ClinicalTrials.gov.


Clinical High Risk Trials at a Glance

11 actively recruiting trials for clinical high risk are listed on ClinicalTrialsFinder across 6 cities in 5 countries. The largest study group is Not Applicable with 9 trials, with the heaviest enrollment activity in New York, Pittsburgh, and Chapel Hill. Lead sponsors running clinical high risk studies include Columbia University, Centre Psychothérapique de Nancy, and Icahn School of Medicine at Mount Sinai.

Browse clinical high risk trials by phase

Treatments under study

About Clinical High Risk Clinical Trials

Looking for clinical trials for Clinical High Risk? There are currently 3 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Clinical High Risk trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Clinical High Risk clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 111 of 11 trials

Recruiting
Not Applicable

Digital Strategies to Advance Help-Seeking - Aim 3

Early PsychosisFirst-episode PsychosisClinical High Risk
Columbia University25,000 enrolled1 locationNCT06774417
Recruiting
Phase 1Phase 2

A Study Exploring Changes in a Variety of Biomarkers Following Dosing With MT1988 in Participants at Clinical High Risk for Psychosis

Clinical High Risk for Psychosis (CHR)
Monument Therapeutics Limited150 enrolled15 locationsNCT07226895
Recruiting

Digital Strategies to Advance Help-Seeking Aim 1 and 2

Early PsychosisFirst-episode PsychosisClinical High Risk
Columbia University25,000 enrolled1 locationNCT06774430
Recruiting
Not Applicable

French Validation of Schizophrenia Proneness Instrument- Child Youth

Clinical High Risk for Psychosis (CHR)
Centre Psychothérapique de Nancy52 enrolled3 locationsNCT06649552
Recruiting
Not Applicable

Experience of UHR and PEP Individuals During Mindfulness: a Qualitative Phenomenological Study

Clinical High Risk for Psychosis (CHR)
Centre Psychothérapique de Nancy20 enrolled2 locationsNCT07499934
Recruiting
Not Applicable

Skills Group for Youth at Clinical High-Risk for Psychosis

PsychologicalClinical High Risk
University of Pittsburgh30 enrolled1 locationNCT05398120
Recruiting
Not Applicable

Telehealth Cognitive Behavioral Therapy for Youth at Risk for Psychosis

Clinical High Risk for Psychosis (CHR)
Icahn School of Medicine at Mount Sinai72 enrolled1 locationNCT05968560
Recruiting
Not Applicable

Sacramento Clinical High Risk for Psychosis Stepped-Care Program

Clinical High Risk for PsychosisUltra High Risk for Psychosis
University of California, Davis223 enrolled6 locationsNCT06640803
Recruiting
Not Applicable

Interventions for Clinical High Risk Youth in Tunisia

Clinical High Risk for Psychosis (CHR)
University of California, Los Angeles54 enrolled1 locationNCT06582901
Recruiting
Not Applicable

Stepped Care for Youth at Risk of Psychosis

Clinical High Risk for Developing Psychosis
University of Calgary60 enrolled1 locationNCT04829292
Recruiting
Not Applicable

Metacognitive Training in Ultra-high Risk

Clinical High Risk for PsychosisUltra High Risk for PsychosisAt-risk Mental State
Medical University of Vienna30 enrolled2 locationsNCT05827900