Phase 1 COVID Clinical Trials
49 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 49 trials
Recruiting
Phase 1
A Safety and Immunogenicity Trial of Boost-2867 Vaccine, Via Intranasal and Intramuscular Routes
COVID-19
National Institute of Allergy and Infectious Diseases (NIAID)140 enrolled8 locationsNCT07221162
Recruiting
Phase 1
A Study of How Ibuzatrelvir is Taken up Into the Blood of Healthy Adults After Taking Different Tablets of Ibuzatrelvir
COVID-19 (Coronavirus Disease 2019)Coronavirus Disease 2019Coronavirus Disease 2019 (COVID-19)
Pfizer18 enrolled1 locationNCT07552779
Recruiting
Phase 1
Safety and Immunogenicity Trial of PepGNP-COVID19 Vaccine in Adults
COVID-19
National Institute of Allergy and Infectious Diseases (NIAID)60 enrolled3 locationsNCT07183709
Recruiting
Phase 1
Study Assessing the Feasibility, Safety and Efficacy of Genetically Engineered Glucocorticoid Receptor Knock Out Virus Specific CTL Lines for Viral Infections in Immunosuppressed Cancer Patients
Malignant Solid NeoplasmHematopoietic and Lymphoid Cell NeoplasmSymptomatic COVID-19 Infection Laboratory-Confirmed+4 more
M.D. Anderson Cancer Center30 enrolled1 locationNCT05101213
Recruiting
Phase 1Phase 2
Study of Cord Blood Derived Mesenchymal Stem Cells for Treatment of Moderate, Severe or Critical Pneumonia
Malignant Solid NeoplasmHematopoietic and Lymphoid Cell NeoplasmCOVID-19 Infection+2 more
M.D. Anderson Cancer Center70 enrolled1 locationNCT04565665
Recruiting
Phase 1
A Study to Assess the Safety and Immunogenicity of a COVID-19 Vaccine Booster in Healthy Adults
COVID-19
University Hospital Tuebingen96 enrolled2 locationsNCT05389319
Recruiting
Phase 1
A Study on the Safety and Immune Response of Investigational mRNA Seasonal Flu/COVID-19 Combination Vaccine in Adults
Influenza, Human+COVID-19
GlaxoSmithKline225 enrolled2 locationsNCT07464314
Recruiting
Phase 1
PET Imaging of Cyclooxygenase-1 in Participants With Neurological Manifestations of Post-Acute Sequelae of SARS-CoV-2 Infection (PASC)
Post Acute Sequelae of COVID-19Long COVID
National Institute of Mental Health (NIMH)60 enrolled1 locationNCT06920628
Recruiting
Phase 1
Positron Emission Tomography (PET) Imaging of Thrombosis
CancerAtrial FibrillationThrombosis+1 more
Massachusetts General Hospital165 enrolled1 locationNCT03830320
Not Yet Recruiting
Phase 1
A study in healthy young adults to compare how safe, well-tolerated, and effective INNA-051 is when given using either a single-use or a multi-use nasal spray system, and to understand participants’ experiences with each.
COVID-19InfluenzaCommon cold
ENA Respiratory Pty Ltd20 enrolled1 locationACTRN12626000037303
Recruiting
Phase 1Phase 2
A Phase 1/2A, Randomized Study of a T Follicular Helper (TFH)-Targeting Genetic Vaccine Strategy Designed to Induce Broad, Durable Immune Responses
COVID-19
Kara Chew80 enrolled2 locationsNCT06810934
Recruiting
Phase 1
Covid-19 and Influenza Oral Vaccine Study
Influenza, Humancovid19 Infection
Vaxine Pty Ltd100 enrolled1 locationNCT06355232
Not Yet Recruiting
Phase 1
Testing the Safety and Effects of the Psychedelic Psilocin on Wellbeing and Anxiety in People with Ongoing Physical and Mental Health Conditions
Chronic Fatigue SyndromeAnorexia NervosaFibromyalgia+6 more
Tryptamine Therapeutics66 enrolled1 locationACTRN12625000949482
Recruiting
Phase 1Phase 2
Safety and Immunogenicity of a Sub-unit Protein CD40.RBDv Bivalent COVID-19 Vaccine, Adjuvanted or Not, as a Booster in Volunteers.
COVID-19
ANRS, Emerging Infectious Diseases215 enrolled2 locationsNCT06255626
Recruiting
Phase 1Phase 2
Medical Herbs Inhibit Inflammation Directing T Cells to Kill the COVID-19 Virus (COVID)
Covid19 Virus Infection
All Natural Medicine Clinic, LLC100 enrolled1 locationNCT04790240
Recruiting
Phase 1
A Multicenter, Randomized, Double-Blind, Placebo-Controlled Clinical Study to Evaluate the Safety and Efficacy of Uterine Blood Mesenchymal Stem Cells Injection for the Treatment of Severe Pneumonia Caused by Viruses
Severe Viral Pneumonia(Not Include COVID-19)
Ruijin Hospital60 enrolled1 locationNCT06693362
Recruiting
Phase 1
A Study of the Efficacy of Troxerutin in Preventing Thrombotic Events in COVID-19 Patients
COVID 19 Associated Coagulopathy
Westlake University80 enrolled1 locationNCT06355258
Not Yet Recruiting
Phase 1
low dose naltrexone in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and long coronavirus disease (long COVID) symptoms
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)Long COVID
Griffith University56 enrolled1 locationACTRN12624001162505
Recruiting
Phase 1Phase 2
Effectiveness and Safety of Mesenchymal Stem Cell Therapy in Long COVID Patients
Post-Acute COVID-19 SyndromeLong COVID
Changhai Hospital76 enrolled1 locationNCT06492798
Completed
Phase 1
A Phase 1, Single Centre, Open Label, Single Dose, Food Effect, Cross Over Study to Investigate the Safety and Pharmacokinetics of Ziverdox in Healthy Volunteers
COVID-19
Topelia Aust Ltd8 enrolled1 locationACTRN12624000833561