Phase 3 Dysfunction Clinical Trials
39 recruitingPhase 3
What is a Phase 3 trial?
Phase 3 trials compare the new treatment against the current standard of care in large groups, often hundreds to thousands of participants. Successful Phase 3 results are typically required for regulatory approval.
Showing 1–20 of 39 trials
Recruiting
Phase 3
A Study to Learn More About How Well Finerenone Works, How Safe it is, and How it Moves Into, Through, and Out of the Body Compared to Placebo When Taken With Standard Treatment in Children With Heart Failure and Left Ventricular Systolic Dysfunction
Left Ventricular Systolic DysfunctionHeart Failure (Pediatric)
Bayer111 enrolled133 locationsNCT07188805
Recruiting
Phase 3
LIVERAGE™ - Cirrhosis: A Study to Test Whether Survodutide Helps People With a Liver Disease Called NASH/MASH Who Have Cirrhosis
Metabolic Dysfunction-Associated Steatohepatitis
Boehringer Ingelheim1,590 enrolled447 locationsNCT06632457
Recruiting
Phase 3
LIVERAGE™: A Study to Test Whether Survodutide Helps People With a Liver Disease Called NASH/MASH Who Have Moderate or Advanced Liver Fibrosis
Metabolic dysfunction-associated steatohepatitis (MASH)Liver Fibrosis
Boehringer Ingelheim1,800 enrolled526 locationsNCT06632444
Recruiting
Phase 3
A Study Evaluating Efruxifermin in Subjects With Compensated Cirrhosis Due to NASH/MASH
MASH - Metabolic Dysfunction-Associated SteatohepatitisNASH - Nonalcoholic Steatohepatitis
Akero Therapeutics, Inc2,150 enrolled322 locationsNCT06528314
Recruiting
Phase 3
A Study to Learn More About How Safe Finerenone is, When it is Taken for a Longer Time With Standard Treatment, in Children and Young Adults With Heart Failure and Left Ventricular Systolic Dysfunction
Left Ventricular Systolic DysfunctionHeart Failure (Pediatric)
Bayer117 enrolled132 locationsNCT07192952
Recruiting
Phase 3
A Master Protocol of Multiple Agents in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (SYNERGY-Outcomes)
Metabolic Dysfunction-Associated Steatotic Liver Disease
Eli Lilly and Company4,500 enrolled561 locationsNCT07165028
Recruiting
Phase 3
A Study to Evaluate the Efficacy and Safety of Pegozafermin in Participants With Compensated Cirrhosis Due to MASH
Metabolic Dysfunction-Associated Steatohepatitis (MASH) / Nonalcoholic Steatohepatitis (NASH) With Compensated Cirrhosis
89bio, Inc.762 enrolled303 locationsNCT06419374
Recruiting
Phase 3
A Study Evaluating the Efficacy and Safety of Pegozafermin in Participants With MASH and Fibrosis (ENLIGHTEN-Fibrosis)
Metabolic Dysfunction-Associated Steatotic Liver Disease (MASH) / Nonalcoholic Steatohepatitis (NASH) With Fibrosis
89bio, Inc.1,350 enrolled349 locationsNCT06318169
Recruiting
Phase 2Phase 3
Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-036)
Heart FailureLeft Ventricular Systolic Dysfunction
Merck Sharp & Dohme LLC342 enrolled106 locationsNCT05714085
Recruiting
Phase 3
AURN001 Efficacy in Participants With Corneal Edema Secondary to Corneal Endothelial Dysfunction
Corneal EdemaCorneal Endothelial DysfunctionFuchs Endothelial Corneal Dysfunction+1 more
Aurion Biotech120 enrolled12 locationsNCT07368959
Recruiting
Phase 3
meChANisms and sAfety of SGLT2 Inhibition in peRitoneal dialYsis
Kidney DysfunctionEnd-stage Kidney DiseasePeritoneal Dialysis Complication+2 more
University Health Network, Toronto20 enrolled1 locationNCT05715814
Recruiting
Phase 3
Exploring Sympathetic Nervous System Function in Individuals With Down Syndrome
Autonomic DysfunctionDown Syndrome
University of Colorado, Denver200 enrolled1 locationNCT07238465
Recruiting
Phase 2Phase 3
Study of Chemosensory Enhancement Through Neuromodulation Training (SCENT for Long COVID)
Long COVIDSmell DysfunctionOlfactory Disorder
Medical University of South Carolina145 enrolled1 locationNCT05855369
Recruiting
Phase 2Phase 3
Mesenchymal Stem Cell and Exosome Therapy for Diabetic Erectile Dysfunction
Erectile Dysfunction With Diabetes Mellitus
Ankara City Hospital Bilkent90 enrolled1 locationNCT07480161
Recruiting
Phase 2Phase 3
Targeted Reversal of Inflammation in Pediatric Sepsis-induced MODS
Pediatric Sepsis-induced Multiple Organ Dysfunction Syndrome (MODS)
Nationwide Children's Hospital500 enrolled32 locationsNCT05267821
Recruiting
Phase 2Phase 3
Effectiveness of Methods for Pyloric Drainage in esophagecTomY: Botox vs. Pyloromyotomy
EsophagectomyEsophageal Cancer SurgeryDelayed Gastric Emptying Following Procedure+4 more
The Cleveland Clinic170 enrolled1 locationNCT06721520
Recruiting
Phase 2Phase 3
Comparing Adjuvant Treatments for High Tone Pelvic Floor Dysfunction
High Tone Pelvic Floor Dysfunction
University of Michigan60 enrolled1 locationNCT07404397
Recruiting
Phase 3
DAPAgliflozine to Attenuate Cardiac RemOdeling afTEr aCuTe myOcardial Infarction
Left Ventricular DysfunctionSTEMIAMI+1 more
Assistance Publique - Hôpitaux de Paris450 enrolled1 locationNCT05764057
Recruiting
Phase 3
Remimazolam vs. Midazolam for Sedation and Cognitive Outcomes in Orthopedic Surgery
Postoperative Pain ManagementPostoperative Cognitive DysfunctionHip Fracture+1 more
Romanian Society for Enteral and Parenteral Nutrition120 enrolled1 locationNCT07113483
Recruiting
Phase 3
Goal-Directed Sedation in Mechanically Ventilated Infants and Children
Post Traumatic Stress DisorderDeliriumCritical Illness+2 more
Vanderbilt University Medical Center372 enrolled1 locationNCT04801589