Phase 2 EOS Clinical Trials
48 recruitingPhase 2
What is a Phase 2 trial?
Phase 2 trials evaluate whether a treatment works for a specific condition and further assess its safety. These studies typically enroll several hundred participants and provide preliminary data on effectiveness.
Showing 1–20 of 48 trials
Recruiting
Phase 1Phase 2
Study of Onivyde With Talazoparib or Temozolomide in Children With Recurrent Solid Tumors and Ewing Sarcoma
Recurrent Malignant Solid NeoplasmRefractory Malignant Solid NeoplasmRecurrent Solid Tumor+19 more
St. Jude Children's Research Hospital90 enrolled10 locationsNCT04901702
Recruiting
Phase 2Phase 3
A Study to Test the Addition of the Drug Cabozantinib to Chemotherapy in Patients With Newly Diagnosed Osteosarcoma
Metastatic OsteosarcomaHigh Grade OsteosarcomaLocalized Osteosarcoma+1 more
National Cancer Institute (NCI)1,122 enrolled194 locationsNCT05691478
Recruiting
Phase 1Phase 2
Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors
Ovarian CarcinomaColorectal CarcinomaMelanoma+19 more
Children's Oncology Group147 enrolled21 locationsNCT04851119
Recruiting
Phase 2
Dupilumab as Add-On Therapy for Hypereosinophilic Syndrome With Partial Clinical Response to Eosinophil-Depleting Biologic Agents
Hypereosinophilic Syndrome
National Institute of Allergy and Infectious Diseases (NIAID)30 enrolled1 locationNCT06477653
Recruiting
Phase 2
A Study in Adult Participants With EoE to Evaluate Vonoprazan 20 mg Compared to Placebo After 12 Weeks and to Evaluate Vonoprazan 20 mg Up to 24 Weeks
eosinophilic esophagitis
Phathom Pharmaceuticals, Inc.80 enrolled41 locationsNCT06851559
Recruiting
Phase 1Phase 2
Lu-TARGO (177Lu-TARGeted Osteosarcoma Therapy)
Relapsed / Refractory Osteosarcoma
Lantheus Medical Imaging55 enrolled2 locationsNCT07357519
Recruiting
Phase 2
A Study of KT-621 Administered Orally to Adult Participants With Moderate to Severe Eosinophilic Asthma
Eosinophilic Asthma
Kymera Therapeutics, Inc.264 enrolled17 locationsNCT07323654
Recruiting
Phase 1Phase 2
NRSTS2021, A Risk Adapted Study Evaluating Maintenance Pazopanib, Limited Margin, Dose-Escalated Radiation Therapy and Selinexor in Non-Rhabdomyosarcoma Soft Tissue Sarcoma (NRSTS)
AngiosarcomaLiposarcomaAdipocytic Neoplasm+6 more
St. Jude Children's Research Hospital139 enrolled6 locationsNCT06239272
Recruiting
Phase 2
Atezolizumab and Cabozantinib for the Treatment of Adolescents and Young Adults With Recurrent or Metastatic Osteosarcoma, TACOS Study
Metastatic OsteosarcomaRecurrent OsteosarcomaRefractory Osteosarcoma+2 more
M.D. Anderson Cancer Center40 enrolled2 locationsNCT05019703
Recruiting
Phase 2
Agnostic Therapy in Rare Solid Tumors
Cancer of Unknown PrimarySoft Tissue SarcomaCholangiocarcinoma+38 more
Instituto do Cancer do Estado de São Paulo28 enrolled8 locationsNCT06638931
Recruiting
Phase 1Phase 2
Study in Children and Adolescents of 177Lu-DOTATATE (Lutathera®) Combined With the PARP Inhibitor Olaparib for the Treatment of Recurrent or Relapsed Solid Tumours Expressing Somatostatin Receptor (SSTR) (LuPARPed).
ParagangliomaPheochromocytomaSolid Tumor Cancer+17 more
Fundación de investigación HM25 enrolled1 locationNCT06607692
Recruiting
Phase 1Phase 2
Silmitasertib (CX-4945) in Combination With Chemotherapy for Relapsed Refractory Solid Tumors
OsteosarcomaEwing SarcomaNeuroblastoma+2 more
Milton S. Hershey Medical Center104 enrolled21 locationsNCT06541262
Recruiting
Phase 1Phase 2
Eflornithine (DFMO) and AMXT 1501 for Neuroblastoma, CNS Tumors, and Sarcomas
OsteosarcomaEwing SarcomaNeuroblastoma+4 more
Milton S. Hershey Medical Center289 enrolled10 locationsNCT06465199
Recruiting
Phase 2
Efficacy and Safety of Vamifeport in Adult Participants With Homeostatic Iron Regulator Gene (HFE)-Related Hereditary Hemochromatosis
Homeostatic Iron Regulator Gene-related Hereditary Hemochromatosis
CSL Behring84 enrolled96 locationsNCT07332091
Recruiting
Phase 2
Trial of Efficacy and Safety of NS-229 Versus Placebo in Patients With Eosinophilic Granulomatosis With Polyangiitis
Eosinophilic Granulomatosis With PolyangiitisChurg-Strauss Syndrome
NS Pharma, Inc.45 enrolled34 locationsNCT06046222
Recruiting
Phase 1Phase 2
A Trial to Evaluate EP-104GI in Adults With Eosinophilic Esophagitis (EoE).
eosinophilic esophagitis
Eupraxia Pharmaceuticals Inc.117 enrolled23 locationsNCT05608681
Recruiting
Phase 1Phase 2
Apatinib Combined With Liposomal Irinotecan for Refractory or Metastatic Osteosarcoma
OsteosarcomaOsteosarcoma Metastatic
Peking University People's Hospital56 enrolled1 locationNCT07479732
Recruiting
Phase 2
A Study of Gefitinib, Trametinib, Disulfiram, and Sunitinib in Addition to Standard Chemotherapy in People With Osteosarcoma
MetastasisOsteosarcoma
Memorial Sloan Kettering Cancer Center45 enrolled7 locationsNCT07477457
Recruiting
Phase 1Phase 2
Alpha/Beta T and B Cell Depletion With Zoledronic Acid for Solid Tumors
OsteosarcomaEwing SarcomaNeuroblastoma+10 more
University of Florida27 enrolled1 locationNCT06625190
Recruiting
Phase 1Phase 2
Study of CAR.70-engineered IL15-transduced Cord Blood-derived NK Cells in Conjunction With Lymphodepleting Chemotherapy for the Management of Advanced Renal Cell Carcinoma, Mesothelioma and Osteosarcoma
Advanced Renal Cell CarcinomaAdvanced MesotheliomaAdvanced Osteosarcoma
M.D. Anderson Cancer Center50 enrolled1 locationNCT05703854