Phase 1 Glioblastoma Multiform Clinical Trials
46 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 46 trials
Recruiting
Phase 1Phase 2
Novel Indenoisoquinolone CMYC/TOPOISOMERASE 1 Inhibitor (LMP744) in Recurrent Glioblastoma
Brain CancerGBMGlioma+12 more
National Institute of Neurological Disorders and Stroke (NINDS)40 enrolled1 locationNCT07416188
Recruiting
Phase 1
A Phase 1 Safety and Dose Finding Study of GLIX1 in Adults With Recurrent or Progressive High-grade Glioma
GlioblastomaGliomaGlioblastoma Multiforme of Brain
Tetragon Biosciences Ltd30 enrolled3 locationsNCT07464925
Recruiting
Phase 1Phase 2
Treatment of Patients With Recurrent High-Grade Glioma With APG-157 and Bevacizumab
GliomaGlioblastoma Multiforme
Aveta Biomics, Inc.30 enrolled2 locationsNCT06011109
Recruiting
Phase 1
A Feasibility Study to Evaluate the Safety of the TheraSphere Glioblastoma (GBM) Device in Patients With Recurrent GBM
Glioblastoma MultiformeRecurrent Glioblastoma
Boston Scientific Corporation36 enrolled9 locationsNCT05303467
Recruiting
Phase 1Phase 2
Oral Capecitabine and Temozolomide (CAPTEM) for Newly Diagnosed GBM
CancerBrain TumorBrain Cancer+6 more
Northwell Health67 enrolled1 locationNCT03213002
Recruiting
Phase 1Phase 2
Repeated Super-selective Intraarterial Cerebral Infusion of Bevacizumab (Avastin) for Treatment of Relapsed GBM and AA
Glioblastoma MultiformeAnaplastic Astrocytoma
Northwell Health54 enrolled1 locationNCT01269853
Recruiting
Phase 1
IL-8 Receptor-modified CD70 CAR T Cell Therapy in CD70+ Adult Glioblastoma
GlioblastomaGlioblastoma Multiforme
University of Florida39 enrolled1 locationNCT05353530
Recruiting
Phase 1Phase 2
Radiation Combined With BIspecific T-Cell Engager in DLL3 Expressing Tumors
Cervical CancerMelanomaNon-small Cell Lung Cancer+8 more
University of Arizona30 enrolled2 locationsNCT06814496
Recruiting
Phase 1
HSV G207 in Children With Recurrent or Refractory Cerebellar Brain Tumors
NeoplasmsNeoplasms by SiteBrain Diseases+30 more
M.D. Anderson Cancer Center24 enrolled3 locationsNCT03911388
Recruiting
Phase 1
Sonodynamic Therapy in Patients With Recurrent GBM
GBMGlioblastoma MultiformeRecurrent Glioblastoma
Shayan Moosa, MD11 enrolled1 locationNCT06039709
Recruiting
Phase 1
Autologous CAR-T Cells Targeting B7-H3 in Recurrent or Refractory GBM CAR.B7-H3Tc
Glioblastoma Multiforme
UNC Lineberger Comprehensive Cancer Center36 enrolled1 locationNCT05366179
Recruiting
Phase 1Phase 2
Safety and Tolerability of TNG456 Alone and in Combination With Abemaciclib in Patients With Solid Tumors With MTAP Loss
Lung CancerNon-small Cell Lung CancerSolid Tumor+4 more
Tango Therapeutics, Inc.191 enrolled15 locationsNCT06810544
Recruiting
Phase 1Phase 2
Safety and Efficacy of Bevacizumab in Combination With NaviFUS System for the Treatment of Recurrent Glioblastoma Multiforme (rGBM)
NeoplasmsBrain TumorGlioblastoma+3 more
NaviFUS Corporation10 enrolled1 locationNCT06329570
Recruiting
Phase 1Phase 2
HSV-tk + Valacyclovir + SBRT + Chemotherapy for Recurrent GBM
Glioblastoma MultiformeAstrocytoma, Grade III
David Baskin MD62 enrolled1 locationNCT03596086
Recruiting
Phase 1Phase 2
A Phase Ib/II Clinical Trial to Evaluate the Safety and Efficacy of JL15003 Injection in Patients With Recurrent Glioblastoma (rGBM)
Recurrent Glioblastoma Multiforme (GBM)
Jecho Biopharmaceuticals Co., Ltd.40 enrolled1 locationNCT07501559
Recruiting
Phase 1Phase 2
Early Phase Study of KESONOTIDE™in Participants With Solid Tumours
Breast CancerLung CancersOvarian Cancer+4 more
Filamon LTD80 enrolled3 locationsNCT06926075
Recruiting
Phase 1Phase 2
Safety and Efficacy Study in Recurrent or Progressive Grade III or IV IDH1 Mutated Glioma
Glioblastoma Multiforme
Neonc Technologies, Inc.49 enrolled12 locationsNCT02704858
Recruiting
Phase 1Phase 2
5G-PEARL: Paxalisib in Malignant Brain Tumours
Glioblastoma Multiforme (GBM)Malignant Primary Gliomas
Institute of Cancer Research, United Kingdom64 enrolled1 locationNCT07391215
Recruiting
Phase 1
GPC-3 CAR T CELLS FOR Recurrent GPC-3 Positive Glioblastoma
Glioblastoma Multiforme of Brain
Baylor College of Medicine27 enrolled1 locationNCT06815432
Recruiting
Phase 1Phase 2
Study of Pembrolizumab and M032 (NSC 733972)
Glioblastoma MultiformeAnaplastic AstrocytomaGliosarcoma
University of Alabama at Birmingham28 enrolled1 locationNCT05084430