Phase 1 Health Clinical Trials
531 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 531 trials
Recruiting
Phase 1
PET Imaging of Phosphodiesterase-4 (PDE4) in Volunteers With Alzheimer Disease (AD) or Mild Cognitive Impairment (MCI)
HealthyMild Cognitive ImpairmentAlzheimer s Disease
National Institute of Mental Health (NIMH)90 enrolled1 locationNCT07169630
Recruiting
Phase 1Phase 2
Suvorexant for Alcohol Use Disorder (AUD): Neural Mechanisms
Healthy VolunteersAlcohol Use Disorder (AUD)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)180 enrolled1 locationNCT06484075
Recruiting
Phase 1
Trametinib and Everolimus for Treatment of Pediatric and Young Adult Patients With Recurrent Gliomas (PNOC021)
High Grade GliomaLow-grade GliomaRecurrent World Health Organization (WHO) Grade II Glioma
University of California, San Francisco50 enrolled17 locationsNCT04485559
Recruiting
Phase 1
A Study of LY3971297 in Healthy Participants
ObesityHypertensionHealthy
Eli Lilly and Company225 enrolled7 locationsNCT06148272
Recruiting
Phase 1Phase 2
A Study to Evaluate BMS-986470 in Healthy Volunteers and Participants With Sickle Cell Disease
Healthy VolunteersAnemia, Sickle Cell
Bristol-Myers Squibb184 enrolled34 locationsNCT06481306
Recruiting
Phase 1
A Study in People With Overweight or Obesity to Compare How 2 Different Formulations of Survodutide Are Taken up by the Body
ObesityHealthyOverweight
Boehringer Ingelheim80 enrolled1 locationNCT07407348
Recruiting
Phase 1
Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive Disorder
DepressionHealthy VolunteerMajor Depressive Disorder
National Institute of Mental Health (NIMH)150 enrolled1 locationNCT03065335
Recruiting
Phase 1
A Study to See How RO7763505 Works and How Safe it is When Given to Healthy People and People With Stable Heart Disease
stable coronary artery diseaseHealthy Volunteers
Hoffmann-La Roche196 enrolled1 locationNCT07495813
Recruiting
Phase 1
A Study to Investigate the Effect of AZD6234, AZD9550, and a Combination of AZD9550 and AZD6234 on Pharmacokinetics of Combined Oral Contraceptive Ethinyl Estradiol/Levonorgestrel in Healthy Female Participants Living With Overweight or Obesity
Healthy Participants
AstraZeneca50 enrolled2 locationsNCT07013643
Recruiting
Phase 1
Dose Escalation Study to Assess the Safety, Tolerability, Pharmacokinetics And Pharmacodynamics of SIF001 in Healthy Subjects and in Epilepsy Patients
EpilepsyHealthy Volunteer
Suninflam Inc88 enrolled10 locationsNCT07051629
Recruiting
Phase 1
Evaluation of [11C]ZTP-1 to Image PDE4B
Healthy
National Institute of Mental Health (NIMH)40 enrolled1 locationNCT07625345
Recruiting
Phase 1
A Study to Assess the Drug Levels and Safety of BMS-986435 in Participants With Normal Hepatic Function and Participants With Different Degrees of Hepatic Impairment
Healthy VolunteersHepatic Impairment
Bristol-Myers Squibb24 enrolled3 locationsNCT07248839
Recruiting
Phase 1
Developing Biomarkers of Dietary Intake: Dose Dependent Measurement of Sugar Intake
Healthy VolunteersDiet Therapy
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)60 enrolled1 locationNCT04799301
Recruiting
Phase 1Phase 2
A Study to Evaluate ALN-4324 in Overweight to Obese Healthy Volunteers and in Overweight to Obese Patients With T2DM
Type 2 Diabetes Mellitus (T2DM)Obese or Overweight Healthy Volunteers
Alnylam Pharmaceuticals144 enrolled22 locationsNCT06845202
Recruiting
Phase 1
A Study to Evaluate ALN-4915 in Adult Healthy Volunteers
Healthy Volunteers
Alnylam Pharmaceuticals44 enrolled1 locationNCT07535606
Recruiting
Phase 1
A Study to Evaluate ALN-4285 in Adult Healthy Volunteers
Healthy Volunteers
Alnylam Pharmaceuticals76 enrolled1 locationNCT07295717
Recruiting
Phase 1
A Study to Evaluate the Effects of KarXT on the Drug Levels of Midazolam, Fexofenadine, and Digoxin
Healthy Volunteers
Karuna Therapeutics, Inc., a Bristol Myers Squibb company60 enrolled1 locationNCT07118215
Recruiting
Phase 1
A Brain Imaging Study to Assess the Binding of MSP-2020 to Serotonin 5-HT2A Receptors in Healthy Male Adults
Healthy Volunteers
Otsuka Pharmaceutical Development & Commercialization, Inc.18 enrolled1 locationNCT07329621
Recruiting
Phase 1
A Study to Understand What the Body Does to the Study Medicine Called PF-07799544 When Taken by Healthy Adults
Healthy male volunteers
Pfizer9 enrolled1 locationNCT07578636
Recruiting
Phase 1
A Study to Investigate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD1043 in Healthy Adult Participants Living With Overweight and/or Obesity.
ObesityHealthy Participants
AstraZeneca104 enrolled3 locationsNCT07511205