Heat Clinical Trials

88 recruitingLast updated: June 18, 2026

There are 88 actively recruiting heat clinical trials across 28 countries. Studies span Not Applicable, Phase 2, Phase 1, Early Phase 1, Phase 4. Top locations include Ottawa, Ontario, Canada, Boston, Massachusetts, United States, New York, New York, United States. Updated daily from ClinicalTrials.gov.


Heat Trials at a Glance

88 actively recruiting trials for heat are listed on ClinicalTrialsFinder across 6 cities in 28 countries. The largest study group is Not Applicable with 47 trials, with the heaviest enrollment activity in Ottawa, Boston, and New York. Lead sponsors running heat studies include University of Ottawa, University of Palermo, and Second Affiliated Hospital, School of Medicine, Zhejiang University.

Browse heat trials by phase

Treatments under study

About Heat Clinical Trials

Looking for clinical trials for Heat? There are currently 1 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Heat trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Heat clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 88 trials

Recruiting
Phase 1

Metarrestin (ML-246) in Subjects With Metastatic Solid Tumors

Advanced Breast CancerAdvanced Solid TumorsMetastatic Pancreatic Cancer+3 more
National Cancer Institute (NCI)116 enrolled2 locationsNCT04222413
Recruiting
Not Applicable

Impact of Heat on Dual Task Performance

HealthyHeat Stress, Exertional
Louisiana State University Health Sciences Center Shreveport10 enrolled1 locationNCT07629414
Recruiting
Not Applicable

Mitigation of Health Effects in Outdoor Workers by Reducing Exposure to Heat and Air Pollution

Heat Strain
University of Cyprus102 enrolled2 locationsNCT07634952
Recruiting

Surveillance for Malignant Transformation of Neurofibromatosis Type 1 (NF1) Related Peripheral Nerve Sheath Tumors (PNST)

Neurofibromatosis 1Nerve Sheath Neoplasms
National Cancer Institute (NCI)225 enrolled1 locationNCT06222203
Recruiting
Phase 2

Tamsulosin and Intraureteral Aminophylline for Ureteral Access During RIRS

Renal StonesRetrograde Intrarenal SurgeryUreteral Access Sheath Placement
Beni-Suef University322 enrolled3 locationsNCT07623876
Recruiting
Early Phase 1

A Window of Opportunity Trial of Mirdametinib Plus Vorinostat for NF1 Associated, H3K27 Trimethylation Deficient Malignant Peripheral Nerve Sheath Tumor [MPNST]

Primary Malignant Peripheral Nerve Sheath Tumors
University of Minnesota8 enrolled1 locationNCT06693284
Recruiting
Not Applicable

PI-YSP-0111 Formulation on Human Gut Microbiota and Body Composition

Heathly Volunteers
Taipei Medical University140 enrolled2 locationsNCT07618000
Recruiting
Not Applicable

Application of an Early In-Hospital Temperature Management Protocol for Heat Stroke Patients

Heat Stroke
Second Affiliated Hospital, School of Medicine, Zhejiang University188 enrolled7 locationsNCT06537557
Recruiting
Not Applicable

Non-inferiority Study of the Effect of Non-cooling Blanket on Body Temperature in Patients With Heat Stroke

Heat Stroke
Second Affiliated Hospital, School of Medicine, Zhejiang University126 enrolled7 locationsNCT05923931
Recruiting
Phase 1

B7-H3-Specific Chimeric Antigen Receptor Autologous T-Cell Therapy for Pediatric Patients With Solid Tumors (3CAR)

Soft Tissue SarcomaMelanomaCarcinoma+13 more
St. Jude Children's Research Hospital48 enrolled1 locationNCT04897321
Recruiting
Not Applicable

NCWS or IBS/FD in Relatives of CD Patients

Celiac DiseaseIBS - Irritable Bowel SyndromeFunctional Dyspepsia+1 more
University of Palermo600 enrolled2 locationsNCT07584473
Recruiting
Not Applicable

Home-based Heat Therapy for Type 2 Diabetes

Diabetes Mellitus, Type 2Heat Exposure
Montreal Heart Institute44 enrolled1 locationNCT05269589
Recruiting
Phase 2

A Study of Selinexor in People With Wilms Tumors and Other Solid Tumors

Solid TumorWilms TumorRhabdoid Tumor+4 more
Memorial Sloan Kettering Cancer Center45 enrolled16 locationsNCT05985161
Recruiting
Not Applicable

Urinary Gluten Immunogenic Peptides Detection in Non-celiac Gluten/Wheat Sensitivity

Non-celiac Gluten/Wheat Sensitivity
University of Palermo40 enrolled2 locationsNCT04219813
Recruiting
Not Applicable

Effects of Hot Baths Prior or After a Damaging Protocol on Muscle Function and HSP70 Expression

RecoveryHeat StressMechanical Stress+3 more
Centre Hospitalier Universitaire, Amiens96 enrolled1 locationNCT07559344
Recruiting

Genetic Risk Factor for Heat Stroke

DehydrationHeat StrokeCarrier State
University of Iowa200 enrolled1 locationNCT06847256
Recruiting

Heat acclimation: Investigating the effect of different core temperature targets on the acute and short term response to passive heat stress when the thermal strain is matched between conditions.

Heat exertion
University of Otago14 enrolled1 locationACTRN12626000487314
Recruiting
Not Applicable

Impact of Indoor Overheating on Physiological Strain in Children

Cognitive ChangePhysiological StressHeat Stress
University of Ottawa10 enrolled1 locationNCT07261202
Recruiting
Not Applicable

Heat Stress in Individuals With Schizophrenia

Cognitive ChangePhysiological StressHeat Stress
University of Ottawa10 enrolled1 locationNCT07383324
Recruiting
Not Applicable

Suitability of the 26 °C Indoor Temperature Upper Limit for Older Adults: Impacts of Clothing and Daily Activity

Physiological StressHeat Stress
University of Ottawa10 enrolled1 locationNCT07189507