Hypercapnic respiratory failure Clinical Trials

10 recruitingLast updated: June 18, 2026

There are 10 actively recruiting hypercapnic respiratory failure clinical trials across 6 countries. Studies span Not Applicable. Top locations include Toronto, Ontario, Canada, New York, New York, United States, Istanbul, Turkey (Türkiye). Updated daily from ClinicalTrials.gov.


Hypercapnic respiratory failure Trials at a Glance

10 actively recruiting trials for hypercapnic respiratory failure are listed on ClinicalTrialsFinder across 6 cities in 6 countries. The largest study group is Not Applicable with 6 trials, with the heaviest enrollment activity in Toronto, New York, and Istanbul. Lead sponsors running hypercapnic respiratory failure studies include Unity Health Toronto, Fisher and Paykel Healthcare, and Başakşehir Çam & Sakura City Hospital.

Browse hypercapnic respiratory failure trials by phase

Treatments under study

About Hypercapnic respiratory failure Clinical Trials

Looking for clinical trials for Hypercapnic respiratory failure? There are currently 3 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Hypercapnic respiratory failure trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Hypercapnic respiratory failure clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 110 of 10 trials

Recruiting

How Nocturnal Hypoventilation Predicts Long-term Response to Non-invasive Ventilation in Hypercapnic COPD Patients

COPDCOPD, Chronic Obstructive Pulmonary DiseaseHypercapnia+1 more
IRCCS Azienda Ospedaliero-Universitaria di Bologna25 enrolled1 locationNCT07414108
Recruiting

The Simplify Project

Acute Hypercapnic Respiratory Failure
Unity Health Toronto50 enrolled1 locationNCT05011877
Recruiting
Not Applicable

High Flow Nasal Cannula Versus Non-Invasive Ventilation in Exacerbations of Chronic Obstructive Pulmonary Disease

Exacerbation CopdAcute Respiratory DistressAcute Hypercapnic Respiratory Failure
Unity Health Toronto30 enrolled1 locationNCT03033251
Recruiting
Not Applicable

The Effects of Music Therapy on Adult Patients Requiring Mechanical Ventilation in the ICU

Acute Hypoxemic Respiratory FailureAcute Hypercapnic Respiratory FailureAcute Respiratory Distress Syndrome
Icahn School of Medicine at Mount Sinai178 enrolled3 locationsNCT03642002
Recruiting

Detecting Systemic Carbon Dioxide Levels With a Novel Biosensor

Hypercapnic respiratory failurePulmonary Disease, Chronic ObstructiveNeuromuscular Diseases+1 more
The Hospital of Vestfold11 enrolled1 locationNCT06367686
Recruiting
Not Applicable

Pilot Physiological Evaluation of an Investigational Mask with Expiratory Washout.

Acute Hypoxemic Respiratory FailureAcute Hypercapnic Respiratory Failure
Fisher and Paykel Healthcare32 enrolled2 locationsNCT06007495
Recruiting
Not Applicable

Closed-Loop O2 Use During High Flow Oxygen Treatment of Critical Care Adult Patients (CLOUDHFOT)

Respiratory FailureAcute Hypoxemic Respiratory FailureAcute Hypercapnic Respiratory Failure+1 more
Başakşehir Çam & Sakura City Hospital50 enrolled2 locationsNCT06374589
Recruiting
Not Applicable

The ROTAtional-USE of Interface STUDY

Acute Hypercapnic Respiratory FailurePressure ulcerNoninvasive Positive Pressure Ventilation
Azienda Ospedaliero Universitaria Maggiore della Carita478 enrolled1 locationNCT05513508
Recruiting
Not Applicable

NIV for Hypercapnic Respiratory Failure: AVAPS vs S/T BIPAP

Hypercapnic respiratory failure
Northwell Health100 enrolled1 locationNCT06047405
Recruiting

Effect of supplemental oxygen in patients with chronic hypercapnic respiratory failure

Chronic hypercapnic respiratory failure due to obesity hypoventilation syndrome
Royal Prince Alfred Hospital28 enrolled1 locationACTRN12608000172303