Phase 1 Immunodeficiency Clinical Trials
11 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–11 of 11 trials
Recruiting
Phase 1Phase 2
Lentiviral Gene Transfer for Treatment of Children Older Than Two Years of Age With X-Linked Severe Combined Immunodeficiency (XSCID)
X-linked Severe Combined Immunodeficiency (XSCID)
National Institute of Allergy and Infectious Diseases (NIAID)40 enrolled1 locationNCT01306019
Recruiting
Phase 1
Lenacapavir Intensification to Disrupt HIV Reservoirs in Virologically Suppressed People With HIV Receiving Antiretroviral Therapy
Human Immunodeficiency Virus
National Institute of Allergy and Infectious Diseases (NIAID)50 enrolled1 locationNCT06819176
Recruiting
Phase 1
HIV Therapeutic DNA Vaccine (ICVAX) Phase I Clinical Trial in Hong Kong
Human Immunodeficiency VirusHuman Immunodeficiency Virus I Infection
Immuno Cure Holding (HK) Limited22 enrolled1 locationNCT07530198
Recruiting
Phase 1Phase 2
Safety and Efficacy Study of Transplantation of Autologous CD34+ Cells Transduced With the G2ARTE Lentiviral Vector Expressing the DCLRE1C cDNA in Artemis (DCLRE1C) Deficient Severe Combined Immunodeficiency Patients (ARTEGENE)
Artemis (DCLRE1C ) Deficient Severe Combined Immunodeficiency
Assistance Publique - Hôpitaux de Paris7 enrolled1 locationNCT05071222
Recruiting
Phase 1Phase 2
Autologous Gene Therapy for Artemis-Deficient SCID
Severe Combined Immunodeficiency
University of California, San Francisco24 enrolled1 locationNCT03538899
Recruiting
Phase 1
Adoptive T Lymphocyte Administration for Chronic Norovirus Treatment in Immunocompromised Hosts
Viral InfectionHematopoietic Stem Cell Transplantation (HSCT)Primary Immunodeficiency Disorders (PID)
Children's National Research Institute48 enrolled3 locationsNCT04691622
Recruiting
Phase 1
The DART DELIVER-02 Study
HIV (Human Immunodeficiency Virus)
University of North Carolina, Chapel Hill24 enrolled3 locationsNCT07217379
Recruiting
Phase 1
Evaluation of Safety and Immunogenicity of Ad26.Mos4.HIV and CH505 TF chTrimer Combination in Healthy Adults
Human Immunodeficiency Virus
U.S. Army Medical Research and Development Command78 enrolled1 locationNCT06205056
Recruiting
Phase 1Phase 2
Phase Ib/IIa Clinical Study of ACC017 Tablets
Infection, Human Immunodeficiency Virus
Jiangsu Aidea Pharmaceutical Group Co., Ltd.36 enrolled1 locationNCT06719310
Recruiting
Phase 1
Lentiviral Gene Therapy for X-linked Severe Combined Immunodeficiency
Severe Combined Immunodeficiency, X-Linked
Great Ormond Street Hospital for Children NHS Foundation Trust5 enrolled1 locationNCT03601286
Completed
Phase 1
A trial of BIT225 in patients with HIV-1 infection, to study the safety, concentration and distribution in the body, and anti-viral activity of the drug.
Human Immunodeficiency Virus-1 infection
Biotron Limited24 enrolled1 locationACTRN12612000696897