Phase 1 Myopathy Clinical Trials
42 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 42 trials
Recruiting
Phase 1
A Study to Investigate the Safety and Preliminary Efficacy of ALLO-329, an Allogeneic CAR T-cell Therapy, in Adults With Autoimmune Disease
Systemic SclerosisIdiopathic Inflammatory MyopathySystemic Lupus Erythematosus (With and Without Nephritis)
Allogene Therapeutics66 enrolled14 locationsNCT07085104
Recruiting
Phase 1
Phase 1b Trial of RAY121 in Immunological Diseases (RAINBOW Trial)
Antiphospholipid Syndrome (APS)Immune-mediated Necrotizing Myopathy (IMNM)Immune Thrombocytopenia (ITP)+3 more
Chugai Pharmaceutical144 enrolled77 locationsNCT06371417
Recruiting
Phase 1
A Safety and Efficacy Study Evaluating CTX112 in Adult Subjects With Refractory Autoimmune Disease
SLE (Systemic Lupus)Diffuse Cutaneous Systemic SclerosisSystemic Sclerosis+4 more
CRISPR Therapeutics80 enrolled14 locationsNCT06925542
Recruiting
Phase 1
A Study of AZD4063 in PLN R14del Dilated Cardiomyopathy
Dilated Cardiomyopathy
AstraZeneca31 enrolled4 locationsNCT07241104
Recruiting
Phase 1Phase 2
Study of ASP2957 in Male Participants With X-linked Myotubular Myopathy Who Need Ventilators
X-linked Myotubular Myopathy
Astellas Gene Therapies9 enrolled4 locationsNCT07052929
Recruiting
Phase 1Phase 2
Safety and Efficacy of FAP iCDC in End-stage Dilated Cardiomyopathy
Heart FailureDilated Cardiomyopathy (DCM)
Second Affiliated Hospital, School of Medicine, Zhejiang University43 enrolled1 locationNCT06902896
Recruiting
Phase 1Phase 2
An AAV Gene Therapy Trial of AFTX-201 in Adults With BAG3-Associated Dilated Cardiomyopathy (DCM)
Dilated Cardiomyopathy (DCM)BAG3 Mutation Associated Dilated Cardiomyopathy
Affinia Therapeutics22 enrolled3 locationsNCT07426419
Recruiting
Phase 1Phase 2
A Study With NVC-001 in Patients With LMNA-related Dilated Cardiomyopathy (SUNBEAM-LMNA)
LMNA-Related Dilated Cardiomyopathy
Nuevocor Pte. Ltd.21 enrolled6 locationsNCT07606274
Recruiting
Phase 1
Safety and Efficacy of FAP iCDC in Ischemic Cardiomyopathy
Cell TherapyIschemic Cardiomyopathy
Second Affiliated Hospital, School of Medicine, Zhejiang University30 enrolled1 locationNCT07505199
Recruiting
Phase 1
Safety and Efficacy of Second Infusion of FAP iCDC in End-stage Dilated Cardiomyopathy
Heart FailureDilated Cardiomyopathy (DCM)
Second Affiliated Hospital, School of Medicine, Zhejiang University5 enrolled1 locationNCT07516288
Recruiting
Phase 1
A Phase 1 AAV Gene Therapy Trial Evaluating Safety and Preliminary Efficacy of RP-A701 in Subjects With BAG3 Dilated Cardiomyopathy
Dilated Cardiomyopathy (DCM)
Rocket Pharmaceuticals Inc.8 enrolled3 locationsNCT07137338
Recruiting
Phase 1
A Bioequivalence Study of Two Formulations of HRS-1893 Tablets in Healthy Participants
Cardiomyopathy
Shandong Suncadia Medicine Co., Ltd.58 enrolled1 locationNCT07479641
Recruiting
Phase 1
A Phase 1 Open-Label Study of the Safety of Intravenous Allogeneic Neonatal Mesenchymal Cells (nMSCs) in Young Adult (1A) and Pediatric (1B) Patients With Dilated Cardiomyopathy (DCM)
Dilated Cardiomyopathy
Emory University36 enrolled5 locationsNCT06464588
Recruiting
Phase 1Phase 2
ALXN2350 in Adult Participants With BAG3-Associated Dilated Cardiomyopathy
BAG3 Mutation Associated Dilated Cardiomyopathy
Alexion Pharmaceuticals, Inc.6 enrolled10 locationsNCT07218887
Recruiting
Phase 1
OM336 in Seropositive Autoimmune Diseases
Idiopathic Inflammatory Myopathy (IIM)Sjogrens Disease
Lakefront Biotherapeutics West LLC39 enrolled1 locationNCT07229144
Recruiting
Phase 1
A Study of CC-97540, CD-19-Targeted Nex-T CAR T Cells, in Participants With Severe, Refractory Autoimmune Diseases (Breakfree-1)
Rheumatoid ArthritisSystemic Lupus ErythematosusSystemic Sclerosis+1 more
Juno Therapeutics, Inc., a Bristol-Myers Squibb Company270 enrolled54 locationsNCT05869955
Recruiting
Phase 1
Phase 1 Study of HBI0101 CAR-T in Refractory B-Cell Autoimmune Diseases
Rheumatoid Arthritis (RA)Systemic Lupus Erythematosus (SLE)Neuromyelitis Optica Spectrum Disorder (NMOSD)+6 more
Polina Stepensky120 enrolled1 locationNCT07085676
Recruiting
Phase 1
A Phase 1, Dose Escalation Trial of RP-A601 in Subjects With PKP2 Variant-Mediated Arrhythmogenic Cardiomyopathy (PKP2-ACM)
PKP2 Arrhythmogenic Cardiomyopathy (PKP2-ACM)
Rocket Pharmaceuticals Inc.9 enrolled3 locationsNCT05885412
Recruiting
Phase 1
A Research Study to Look at the Distribution and Effects of Coramitug on Amyloid Deposits in Heart Tissue Using PET/CT Imaging in People With ATTR Amyloidosis.
Transthyretin Amyloid Cardiomyopathy
Novo Nordisk A/S14 enrolled1 locationNCT07448623
Recruiting
Phase 1Phase 2
Multi-center, Open-label, Single-ascending Dose Study of Safety and Tolerability of TN-201 in Adults With Symptomatic MYBPC3 Mutation-associated HCM
Hypertrophic Cardiomyopathy
Tenaya Therapeutics30 enrolled10 locationsNCT05836259