Early Phase 1 Neoplasm Clinical Trials
24 recruitingEarly Phase 1
What is a Early Phase 1 trial?
Early Phase 1 trials are the earliest stage of testing in humans. These small studies focus on how a drug is processed in the body and how it affects the body, often enrolling just a handful of participants to establish initial safety data.
Showing 1–20 of 24 trials
Recruiting
Early Phase 1
A Phase 0/1 Study of cDNA for TP53, Checkpoint Inhibition and Radiation in Children With Recurrent, Progressive or Refractory CNS Malignancies.
PineoblastomaMedulloblastoma RecurrentEpendymoma Recurrent+3 more
Children's National Research Institute18 enrolled1 locationNCT07017816
Recruiting
Early Phase 1
Addition of Cord Blood Tissue-Derived Mesenchymal Stromal Cells to Ruxolitinib for the Treatment of Steroid-Refractory Acute Graft Versus Host Disease
Hematopoietic and Lymphoid Cell Neoplasm
M.D. Anderson Cancer Center24 enrolled1 locationNCT04744116
Recruiting
Early Phase 1
Momelotinib in Combination With Hypomethylating Agent for Chronic Phase Myelodysplastic Syndromes/Myeloproliferative Overlap Neoplasms and Chronic Neutrophilic Leukemia
Myelodysplastic SyndromesChronic Myelomonocytic LeukemiaMyeloproliferative Overlap Neoplasms+1 more
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins18 enrolled1 locationNCT07071155
Recruiting
Early Phase 1
L-Theanine to Support Relaxation and Mood for Cancer Patients in Surveillance
Hematopoietic and Lymphatic System NeoplasmMalignant Solid Neoplasm
City of Hope Medical Center50 enrolled4 locationsNCT07220447
Recruiting
Early Phase 1
In-Human CXCR4 Imaging of Hematologic and Solid Tumors Using [68Ga]-Pentixafor-PET
Non-Hodgkin LymphomaMultiple MyelomaErdheim-Chester Disease+1 more
Memorial Sloan Kettering Cancer Center30 enrolled1 locationNCT05093335
Recruiting
Early Phase 1
CART123 T Cells in Relapsed or Refractory CD123+ Hematologic Malignancies: A Dose Escalation Phase I Trial
Myelodysplastic Syndromes (MDS)Precursor Cell Lymphoblastic Leukemia-LymphomaBlastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)+1 more
Institute of Hematology and Blood Transfusion, Czech Republic18 enrolled1 locationNCT06765876
Recruiting
Early Phase 1
Alteplase Through an Indwelling Pleural Catheter for the Management of Symptomatic Septated Malignant Pleural Effusion
Malignant Solid NeoplasmHematopoietic and Lymphoid Cell Neoplasm
M.D. Anderson Cancer Center30 enrolled1 locationNCT06184321
Recruiting
Early Phase 1
Virtual Histology of the Bladder Wall for Bladder Cancer Staging
Urinary Bladder Neoplasms
Jodi Maranchie42 enrolled1 locationNCT04369560
Recruiting
Early Phase 1
Arginine and Whole Brain Radiation Therapy for the Treatment of Patients With Brain Metastases
Metastatic Malignant Solid NeoplasmMetastatic Malignant Neoplasm in the Brain
Emory University10 enrolled1 locationNCT06328686
Recruiting
Early Phase 1
A Molecular Probe Targeting BCMA for the Clinical Diagnosis of Multiple Myeloma
Multiple Myeloma and Malignant Plasma Cell Neoplasms
Peking University First Hospital50 enrolled2 locationsNCT06717113
Recruiting
Early Phase 1
Prospective Screening for Pancreatic Ductal Adenocarcinoma in High-Risk Individuals
Pancreatic CancerPancreatic Ductal AdenocarcinomaPDAC+2 more
Dana-Farber Cancer Institute5,000 enrolled2 locationsNCT06122896
Recruiting
Early Phase 1
Study of KRAS Neoantigen mRNA Vaccine (ABO2102) in Patients With KRAS -Mutated Solid Tumors
Pancreatic NeoplasmsOther Solid Tumors
Ruijin Hospital56 enrolled1 locationNCT06577532
Recruiting
Early Phase 1
Study on the Clinical Application Value of PET Imaging Targeting GPC3 in Hepatocellular Carcinoma
Malignant Neoplasm of Liver
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology100 enrolled1 locationNCT06383520
Recruiting
Early Phase 1
Hyperbaric Oxygen Therapy and Allogeneic Peripheral Blood Stem Cell (PBSC) Transplant
Acute Myeloid LeukemiaMyelodysplastic SyndromesChronic Myelomonocytic Leukemia+4 more
Omar Aljitawi24 enrolled1 locationNCT03964506
Recruiting
Early Phase 1
Safety and Efficacy of Intravenous IDOV-SAFETM in Patients With Advanced Solid Tumors
Neoplasms
Cancer Institute and Hospital, Chinese Academy of Medical Sciences19 enrolled1 locationNCT06346041
Recruiting
Early Phase 1
18F-FAPIBiotin PET/CT: Dosimetry and Biodistribution Study
Malignant Neoplasm
First Affiliated Hospital of Fujian Medical University5 enrolled1 locationNCT06734572
Recruiting
Early Phase 1
68Ga-JH04 PET/CT: Dosimetry and Biodistribution Studies
Malignant Neoplasm
First Affiliated Hospital of Fujian Medical University5 enrolled1 locationNCT06438250
Recruiting
Early Phase 1
68Ga-JH12 PET/CT: Dosimetry and Biodistribution Study
Malignant Neoplasm
First Affiliated Hospital of Fujian Medical University5 enrolled1 locationNCT06688188
Recruiting
Early Phase 1
68Ga-NI-FAPI PET/CT: First-in-human Study
Malignant Neoplasm
First Affiliated Hospital of Fujian Medical University40 enrolled1 locationNCT06688305
Recruiting
Early Phase 1
68Ga-FAPI-RGD PET/CT Imaging in the Lung Cancer Patients
Lung Neoplasms
Peking Union Medical College Hospital60 enrolled1 locationNCT05543954