Early Phase 1 OME Clinical Trials
63 recruitingEarly Phase 1
What is a Early Phase 1 trial?
Early Phase 1 trials are the earliest stage of testing in humans. These small studies focus on how a drug is processed in the body and how it affects the body, often enrolling just a handful of participants to establish initial safety data.
Showing 1–20 of 63 trials
Recruiting
Early Phase 1
Palliative Care Integration in Pediatric Oncology Phase 1 Clinical Trials
Quality of Life Outcomes
Phoenix Children's Hospital30 enrolled3 locationsNCT07696065
Recruiting
Early Phase 1
MTS109 in Patients With Refractory Autoimmune Diseases
Systemic Lupus ErythematosusIdiopathic Inflammatory MyopathiesSystemic Sclerosis (SSc)+2 more
Shanghai Changzheng Hospital15 enrolled1 locationNCT07526350
Recruiting
Early Phase 1
Placebo-controlled Study of Single and Multiple Ascending Doses of UDP-003 in Healthy Human Participants and Followed by an Open-label Patient Cohort
Atherosclerotic Cardiovascular DiseaseAcute Coronary Syndromes
Cyclarity Therapeutics, Inc.84 enrolled1 locationNCT06813339
Recruiting
Early Phase 1
A Study of Short-Course Radiation Therapy With Chemotherapy in People With Endometrial Cancer
Endometrial CancerEndometrial CarcinomaStage III Endometrial Cancer+2 more
Memorial Sloan Kettering Cancer Center28 enrolled7 locationsNCT05691010
Recruiting
Early Phase 1
A Study to Evaluate the Safety and Pharmacokinetics of RC001 in Children With Dravet Syndrome
Dravet Syndrome (DS)
Second Affiliated Hospital of Guangzhou Medical University8 enrolled1 locationNCT07675746
Recruiting
Early Phase 1
Efficacy, Safety, and Pharmacokinetics of ThisCART19A Combined With Olverembatinib in Patients With Newly Diagnosed Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia.
Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia
The First Affiliated Hospital of Soochow University20 enrolled2 locationsNCT07074496
Recruiting
Early Phase 1
A Single Dose, Dose Escalation Clinical Trial on the Safety, Tolerability and Efficacy of Lyophilized Powder for Inhalation of Recombinant Human Keratinocyte Growth Factor-2 (Rh-KGF-2) in The Treatment of Patients With Acute Respiratory Distress Syndrome
ARDS (Moderate or Severe)ARDS (Acute Respiratory Distress Syndrome)
Shanghai Zhongshan Hospital24 enrolled1 locationNCT07558538
Recruiting
Early Phase 1
Hyperbaric Oxygen Therapy and Allogeneic Peripheral Blood Stem Cell (PBSC) Transplant
Acute Myeloid LeukemiaMyelodysplastic SyndromesChronic Myelomonocytic Leukemia+4 more
Omar Aljitawi24 enrolled1 locationNCT03964506
Recruiting
Early Phase 1
Development of a Preparation for Supportive Supplementation of Probiotics in Patients With Reflux
MicrobiomeReflux DiseaseProbiotics Supplement
University Hospital Olomouc50 enrolled1 locationNCT07600008
Recruiting
Early Phase 1
5-Azacitidine and Decitabine Epigenetic Therapy for Myeloid Malignancies
Myelodysplastic SyndromesMDS/MPN Crossover Syndromes
Benjamin Tomlinson20 enrolled1 locationNCT04187703
Recruiting
Early Phase 1
Functional Neuroimaging to Detect the Neural Signatures of the Unpleasantness of Pain and Effort
Fatigue Syndrome, Chronic
National Institute of Neurological Disorders and Stroke (NINDS)47 enrolled1 locationNCT06472622
Recruiting
Early Phase 1
CD19/BCMA UCAR-T for B Cell-Related Autoimmune Disease
IgA Nephropathy (IgAN)Autoimmune DiseasesSystemic Sclerosis (SSc)+3 more
The Children's Hospital of Zhejiang University School of Medicine15 enrolled1 locationNCT07586267
Recruiting
Early Phase 1
Real-Time Atherosclerosis Activity After Thoracic Radiotherapy Using Sodium Fluoride Positron Emission Tomography
Oligometastatic Disease
Katelyn Atkins10 enrolled1 locationNCT06373497
Recruiting
Early Phase 1
Tirzepatide in Obesity-Driven Endometrial Cancer
Endometrial CancerObesity
UNC Lineberger Comprehensive Cancer Center20 enrolled1 locationNCT07065552
Recruiting
Early Phase 1
Donor Virus-Specific CMV or AdV CTL to Treat CMV or AdV Reactivation or Disease After Solid Organ or HCT
Allogeneic Hematopoietic Stem Cell Transplantation RecipientAdenovirusCytomegalovirus+2 more
Sumithira Vasu20 enrolled2 locationsNCT03665675
Recruiting
Early Phase 1
A Study of a Weight Loss Intervention in People With Endometrial Cancer
Endometrial Cancer
Memorial Sloan Kettering Cancer Center36 enrolled7 locationsNCT06751589
Recruiting
Early Phase 1
Allogeneic CD19/BCMA CAR-T for B Cell-Related Autoimmune Disease
IgA Nephropathy (IgAN)Autoimmune DiseasesSystemic Sclerosis (SSc)+3 more
The Children's Hospital of Zhejiang University School of Medicine15 enrolled1 locationNCT07507201
Recruiting
Early Phase 1
Momelotinib in Combination With Hypomethylating Agent for Chronic Phase Myelodysplastic Syndromes/Myeloproliferative Overlap Neoplasms and Chronic Neutrophilic Leukemia
Myelodysplastic SyndromesChronic Myelomonocytic LeukemiaMyeloproliferative Overlap Neoplasms+1 more
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins18 enrolled1 locationNCT07071155
Recruiting
Early Phase 1
Clinical Study on Targeted CD19 or CD19-BCMA CAR-T Therapy for Autoimmune Diseases
Sjogren's SyndromeAutoimmune DiseasesIdiopathic Inflammatory Myopathies+3 more
Nanjing Bioheng Biotech Co., Ltd.20 enrolled1 locationNCT06548607
Recruiting
Early Phase 1
Tadekinig Alfa (IL-18BP) Rescue Therapy for CAR T Cell Related Cytokine Release Syndrome (CRS) and HLH-like Syndrome
CRS - Cytokine Release SyndromeHLH
University of Pennsylvania10 enrolled1 locationNCT05306080