Early Phase 1 OME Clinical Trials
57 recruitingEarly Phase 1
What is a Early Phase 1 trial?
Early Phase 1 trials are the earliest stage of testing in humans. These small studies focus on how a drug is processed in the body and how it affects the body, often enrolling just a handful of participants to establish initial safety data.
Showing 1–20 of 57 trials
Recruiting
Early Phase 1
Real-Time Atherosclerosis Activity After Thoracic Radiotherapy Using Sodium Fluoride Positron Emission Tomography
Oligometastatic Disease
Katelyn Atkins10 enrolled1 locationNCT06373497
Recruiting
Early Phase 1
Tirzepatide in Obesity-Driven Endometrial Cancer
Endometrial CancerObesity
UNC Lineberger Comprehensive Cancer Center20 enrolled1 locationNCT07065552
Recruiting
Early Phase 1
MTS109 in Patients With Refractory Autoimmune Diseases
Systemic Lupus ErythematosusIdiopathic Inflammatory MyopathiesSystemic Sclerosis (SSc)+2 more
Shanghai Changzheng Hospital15 enrolled1 locationNCT07526350
Recruiting
Early Phase 1
Donor Virus-Specific CMV or AdV CTL to Treat CMV or AdV Reactivation or Disease After Solid Organ or HCT
Allogeneic Hematopoietic Stem Cell Transplantation RecipientAdenovirusCytomegalovirus+2 more
Sumithira Vasu20 enrolled2 locationsNCT03665675
Recruiting
Early Phase 1
A Study of a Weight Loss Intervention in People With Endometrial Cancer
Endometrial Cancer
Memorial Sloan Kettering Cancer Center36 enrolled7 locationsNCT06751589
Recruiting
Early Phase 1
Allogeneic CD19/BCMA CAR-T for B Cell-Related Autoimmune Disease
IgA Nephropathy (IgAN)Autoimmune DiseasesSystemic Sclerosis (SSc)+3 more
The Children's Hospital of Zhejiang University School of Medicine15 enrolled1 locationNCT07507201
Recruiting
Early Phase 1
Momelotinib in Combination With Hypomethylating Agent for Chronic Phase Myelodysplastic Syndromes/Myeloproliferative Overlap Neoplasms and Chronic Neutrophilic Leukemia
Myelodysplastic SyndromesChronic Myelomonocytic LeukemiaMyeloproliferative Overlap Neoplasms+1 more
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins18 enrolled1 locationNCT07071155
Recruiting
Early Phase 1
Clinical Study on Targeted CD19 or CD19-BCMA CAR-T Therapy for Autoimmune Diseases
Sjogren's SyndromeAutoimmune DiseasesIdiopathic Inflammatory Myopathies+3 more
Nanjing Bioheng Biotech Co., Ltd.20 enrolled1 locationNCT06548607
Recruiting
Early Phase 1
Tadekinig Alfa (IL-18BP) Rescue Therapy for CAR T Cell Related Cytokine Release Syndrome (CRS) and HLH-like Syndrome
CRS - Cytokine Release SyndromeHLH
University of Pennsylvania10 enrolled1 locationNCT05306080
Recruiting
Early Phase 1
UCAR-T Targeting CD19/BCMA in Subjects With Autoantibody-Mediated Autoimmune Benign Hematological Diseases
Autoimmune Hemolytic AnemiaEvans SyndromePrimary Immune Thrombocytopenic Purpura
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology27 enrolled1 locationNCT07441525
Recruiting
Early Phase 1
Exploratory Clinical Study on the Safety and Efficacy of Anti- CD19/BCMA U CAR-T Cell Injection for the Treatment of Relapsed/Refractory Autoimmune Diseases
Rheumatoid ArthritisSystemic Lupus ErythematosusAnti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis+3 more
Changhai Hospital60 enrolled1 locationNCT07246096
Recruiting
Early Phase 1
Placebo-controlled Study of Single and Multiple Ascending Doses of UDP-003 in Healthy Human Participants and Patients
Atherosclerotic Cardiovascular DiseaseAcute Coronary Syndromes
Cyclarity Therapeutics, Inc.84 enrolled1 locationNCT06813339
Recruiting
Early Phase 1
Expanded Access Protocol Using CD3+/CD19+ Depleted PBSC
LeukemiaInborn Errors of MetabolismBone Marrow Failure Syndromes+2 more
Children's Hospital of Philadelphia100 enrolled1 locationNCT02356653
Recruiting
Early Phase 1
177Lu-anti-PD-L1 sdAb in Metastatic Solid Tumors
Endometrial CancerNon-small Cell Lung CancerTNBC - Triple-Negative Breast Cancer+6 more
Radiopharm Theranostics, Ltd30 enrolled5 locationsNCT06305962
Recruiting
Early Phase 1
Open-Label Pilot Study With Crofelemer in Patients With Short Bowel Syndrome
Short Bowel Syndrome
Lindsey Russell, MD6 enrolled1 locationNCT06326645
Recruiting
Early Phase 1
Hyperthermic Intraperitoneal Chemotherapy With Cisplatin During Surgery or Cisplatin Before Surgery for the Treatment of Stage III or IV Ovarian, Fallopian Tube or Peritoneal Cancer
Stage III Ovarian Cancer AJCC v8Stage IV Ovarian Cancer AJCC v8Stage IIIA Ovarian Cancer AJCC v8+30 more
Ohio State University Comprehensive Cancer Center45 enrolled1 locationNCT05415709
Recruiting
Early Phase 1
CS-121 APOC3 Base Editing in FCS
Familial Chylomicronemia Syndrome (FCS)
CorrectSequence Therapeutics Co., Ltd15 enrolled1 locationNCT07176923
Recruiting
Early Phase 1
The Effect of Therapy Combination in PCOS With Dlbs 3233
Polycystic Ovary Syndrome
Inlacinpenelitian90 enrolled1 locationNCT07403201
Recruiting
Early Phase 1
A Study of Short-Course Radiation Therapy With Chemotherapy in People With Endometrial Cancer
Endometrial CancerEndometrial CarcinomaStage III Endometrial Cancer+2 more
Memorial Sloan Kettering Cancer Center28 enrolled7 locationsNCT05691010
Recruiting
Early Phase 1
A Clinical Study Evaluating the Safety and Efficacy of GT719 Universal Cell Injection in the Treatment of Immune-mediated Kidney Diseases
IgA Nephropathy (IgAN)Membranous NephropathyANCA-associated Vasculitis (AAV)/ANCA-associated Glomerulonephritis (AAGN)+2 more
Grit Biotechnology30 enrolled1 locationNCT07389499