Phase 3 Risk Clinical Trials
45 recruitingPhase 3
What is a Phase 3 trial?
Phase 3 trials compare the new treatment against the current standard of care in large groups, often hundreds to thousands of participants. Successful Phase 3 results are typically required for regulatory approval.
Showing 1–20 of 45 trials
Recruiting
Phase 3
Trial of Nadofaragene Firadenovec vs. Observation in Participants With Intermediate Risk Non-Muscle Invasive Bladder Cancer
Intermediate Risk Non-Muscle Invasive Bladder Cancer
Ferring Pharmaceuticals454 enrolled94 locationsNCT06510374
Recruiting
Phase 2Phase 3
A Safety and Efficacy Study of hu14 in High-Risk Neuroblastoma Patients
High Risk Neuroblastoma
Renaissance Pharma Ltd.144 enrolled2 locationsNCT07549321
Recruiting
Phase 3
Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease
HypertensionHigh Risk Cardiovascular DiseaseHigh Cardiovascular Risk
Alnylam Pharmaceuticals11,000 enrolled597 locationsNCT07181109
Recruiting
Phase 3
ARTEMIS - A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With a Heart Attack
Cardiovascular RiskAcute Myocardial Infarction (AMI)
Novo Nordisk A/S10,000 enrolled970 locationsNCT06118281
Recruiting
Phase 3
AVAJAK: Apixaban/Rivaroxaban Versus Aspirin for Primary Prevention of Thrombo-embolic Complications in JAK2V617F-positive Myeloproliferative Neoplasms
Polycythemia VeraEssential ThrombocythemiaHigh Risk Patients+2 more
University Hospital, Brest1,308 enrolled42 locationsNCT05198960
Recruiting
Phase 3
Assessment of Short Immunotherapy After Radical Surgery of High-risk Malignant Melanoma
High-risk Melanoma
Uppsala University1,792 enrolled26 locationsNCT06488482
Recruiting
Phase 3
Study to Compare Axicabtagene Ciloleucel With Standard of Care Therapy as First-line Treatment in Participants With High-risk Large B-cell Lymphoma
High-risk Large B-cell Lymphoma (LBCL)
Kite, A Gilead Company300 enrolled90 locationsNCT05605899
Recruiting
Phase 2Phase 3
Co-infusion of Treg-enriched Donor Lymphocytes With CD3-depleted Hematopoietic Stem Cell Graft to Prevent Graft-versus Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation Among Children With Hematologic Malignancies
Acute Myeloid Leukemia, RelapsedAcute Lymphoblastic Leukemia, High RiskAcute Myeloid Leukemia, High Risk+1 more
Federal Research Institute of Pediatric Hematology, Oncology and Immunology64 enrolled1 locationNCT07366801
Recruiting
Phase 2Phase 3
Resources, Inspiration, Support and Empowerment (RISE) for Black Pregnant Women
DepressionAnxietyInflammation+9 more
Cedars-Sinai Medical Center150 enrolled1 locationNCT05552053
Recruiting
Phase 3
Effect of Metformin Use on Weight Loss in Obese, Non-diabetic People (MOWRI)
Insulin ResistanceObesity and Cardiovascular RiskObesity (Body Mass Index >30 kg/m2)
University Of Nigeria Teaching Hospital220 enrolled2 locationsNCT07297290
Recruiting
Phase 3
Lisaftoclax (APG-2575) Combined With Azacytidine (AZA) in the Treatment of Patients With Higher-risk Myelodysplastic Syndrome (GLORA-4).
Higher-Risk Myelodysplastic Syndrome
Ascentage Pharma Group Inc.490 enrolled2 locationsNCT06641414
Recruiting
Phase 3
Transdermal Patch for BupRenorphine Induction DurinG PrEgnancy (Patch BRIDGE)
Pregnancy ComplicationsOpioid-use DisorderPregnancy Related+2 more
Washington University School of Medicine40 enrolled1 locationNCT05790252
Recruiting
Phase 3
Systematic Radioiodine Administration Versus Decision of Radioiodine Treatment Guided by a Post-operative Work-up
Thyroid CancerIntermediate Risk
Centre Francois Baclesse476 enrolled29 locationsNCT04290663
Recruiting
Phase 3
A Comparative Study to Valuating the Efficacy and Safety of QL1206 and Prolia®
Postmenopausal Women With Osteoporosis at High Risk of Fracture
Qilu Pharmaceutical Co., Ltd.278 enrolled1 locationNCT07062978
Recruiting
Phase 3
High-Risk Neuroblastoma Study 2 of SIOP-Europa-Neuroblastoma (SIOPEN)
High Risk NeuroblastomaPatient With Insufficient Response Chemoimmunotherapy
Gustave Roussy, Cancer Campus, Grand Paris800 enrolled142 locationsNCT04221035
Recruiting
Phase 3
Study Evaluating the Efficacy and Safety of Darolutamide and Stereotactic Dose Escalated Radiotherapy in Patients With Localized Prostate Cancer and High-risk Features of Relapse
Prostate CancerHigh Risk Prostate Carcinoma
UNICANCER700 enrolled6 locationsNCT06625970
Recruiting
Phase 3
Feasibility of Allogeneic Stem Cell Transplantation in Higher-risk-MDS (ACROBAT)
High-risk MDS
Gruppo Italiano Malattie EMatologiche dell'Adulto274 enrolled46 locationsNCT04184505
Recruiting
Phase 3
HVA vs IA/DA or VA in the Treatment of ND HR-AML
Newly Diagnosed Acute Myeloid Leukemia With High Risk
Nanfang Hospital, Southern Medical University876 enrolled1 locationNCT06810791
Recruiting
Phase 3
Circulating Tumor DNA Methylation Guided Postoperative Adjuvant Chemotherapy for High-risk Stage II/III Colorectal Cancer
High-risk Stage II Colorectal CancerStage III Colorectal CancerCirculating Tumor DNA Methylation
Fudan University340 enrolled1 locationNCT05954078
Recruiting
Phase 3
Maintenance Therapy With Toripalimab and Capecitabine Versus Capecitabine Alone in High-risk Nasopharyngeal Carcinoma
Nasopharyngeal CarcinomaHigh-Risk CancerMaintenance Therapy
Jiangxi Provincial Cancer Hospital264 enrolled3 locationsNCT06277050