Phase 1 RNA Clinical Trials
12 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–12 of 12 trials
Recruiting
Phase 1
Clinical Trial of IL - 22BP Safety, Tolerability, and Antitumor Activity in Refractory Solid Tumors.
Refractory Malignant Solid TumorsmRNA VaccineInterleukin
West China Hospital6 enrolled2 locationsNCT07040943
Recruiting
Phase 1
A Phase I Clinical Trial to Evaluate CMS-D017 Following Single and Multiple Doses in Healthy Participants
Paroxysmal Nocturnal Hemoglobinuria, PNHComplement-mediated Kidney Disease
Shenzhen Kangzhe Biotechnology Co., Ltd.88 enrolled1 locationNCT07462780
Recruiting
Phase 1Phase 2
Study to Evaluate the Safety and Immunogenicity of a Lyophilized Herpes Zoster Virus mRNA Vaccine
Herpes ZostermRNA Vaccine
Sinovac Biotech Co., Ltd519 enrolled1 locationNCT07400003
Recruiting
Phase 1
A Clinical Trial Evaluating IL-22BP/LNP Compound in Refractory Malignant Solid Tumors for Safety, Tolerability and Activity
Refractory Malignant Solid TumorsmRNA VaccineInterleukin
Xingchen Peng6 enrolled1 locationNCT07100210
Recruiting
Phase 1
A Phase Ib, Multicenter, Open-Label Study of Multiple-Dose EA5 in Adults With Paroxysmal Nocturnal Hemoglobinuria (PNH)
PNH - Paroxysmal Nocturnal Hemoglobinuria
Shanghai Lanyi Therapeutics Co., Ltd.24 enrolled2 locationsNCT07256301
Recruiting
Phase 1
Dexmedetomidine an Effective Drug in Reducing Anesthetic Requirements in External Dacrocystorhinostomy (DCR) Patients
Patients Undergoing External Dacrocystorhinostomy OperationsAssess Decreased Anesthetic Requirements Intraoperative
Research Institute of Ophthalmology, Egypt24 enrolled1 locationNCT06808295
Completed
Phase 1
A randomised, double-blind, single-dose study to evaluate the pharmacokinetic, safety, tolerability, immunogenicity and pharmacodynamic profile of ISU305 compared to Soliris® (Eculizumab) in Healthy Male Volunteers
Atypical haemolytic uraemic syndrome (aHUS)Paroxysmal nocturnal haemoglobinuria (PNH)
ISU Abxis148 enrolled2 locationsACTRN12619000694112
Completed
Phase 1
The In vivo assessment of a thermoresponsive otic gel in healthy individuals. Phase 1 trial.
Otitis Externa
University of Queensland15 enrolled1 locationACTRN12618001517268
Completed
Phase 1
A Phase 2 placebo controlled, double-blind randomised clinical trial assessing the efficacy of a Herbal supplement for Nocturnal Enuresis in Children
Nocturnal enuresis in children
Endeavour College of Natural Health62 enrolled1 locationACTRN12618000288224
Recruiting
Phase 1
focal radiotherapy for previously treated prostate cancer patients
locally recurrent prostate cancer following definitive external beam radiotherapy
Northern Sydney Local Health District-Royal North Shore Hospital36 enrolled1 locationACTRN12617000035325
Withdrawn
Phase 1
A trial to evaluate the effect of Flex-Aid beverage on frequency of nocturnal foot and/or leg cramps and its safety and tolerability
Nocturnal foot and/or leg cramps
Flex Pharma, Inc.80 enrolled1 locationACTRN12615001245583
Completed
Phase 1
A first in human study assessing the safety and pharmacokinetics (blood levels) of RA101495.
Paroxysmal nocturnal hemoglobinuria
Clinical Network Services Pty Ltd40 enrolled1 locationACTRN12615001143516