SPAST Clinical Trials

1 recruiting

Frequently Asked Questions

Common questions about SPAST clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 122 trials

Recruiting

Classification of Upper and Lower Limb Spasticity Patterns and Their Impact on Quality of Life in Patients With Multiple Sclerosis

Multiple SclerosisSpasticitySpasticity With Multiple Sclerosis
Marmara University75 enrolled1 locationNCT07466823
Recruiting
Phase 3

A Study on Recombinant Botulinum Toxin Type A (YY001) for Injection in Multiple Treatments of Adult Upper Limb Spasticity

Upper Limb Spasticity
Chongqing Claruvis Pharmaceutical Co., Ltd.300 enrolled16 locationsNCT07478822
Recruiting
Not Applicable

Effect of Task Specific Electrical Stimulation on Upper Limb Gross Motor Skills in Children With Spastic Quadriplegia

Spastic Cerebral PalsyCerebral Palsy (CP)Upper Limb Function+2 more
Kafrelsheikh University30 enrolled1 locationNCT06925425
Recruiting
Phase 1

Shockwave for Elbow and Wrist Spasticity in People With Spinal Cord Injury

Spinal Cord InjurySpasticityShockwave Therapy
Kessler Foundation12 enrolled1 locationNCT07501429
Recruiting

Neurosurgical Outcome Network

Trigeminal NeuralgiaHydrocephalusSubarachnoid Hemorrhage+14 more
Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta4,500 enrolled27 locationsNCT06724029
Recruiting

STOP-HSP.Net: a Registry for Hereditary Spastic Paraplegia as an Integration Tool for Future Therapeutic Strategies

Hereditary Spastic Paraplegia
IRCCS Fondazione Stella Maris500 enrolled1 locationNCT06572046
Recruiting
Not Applicable

Biomarkers of Reaction To HIIT Exercise

Stroke RehabilitationStrokeWalking, Difficulty+1 more
VA Office of Research and Development55 enrolled1 locationNCT06059872
Recruiting
Phase 2

A Study to Evaluate the Efficacy, Safety and Tolerability of BMS-986368 in Participants With Multiple Sclerosis Spasticity

Multiple Sclerosis Spasticity
Celgene200 enrolled53 locationsNCT06782490
Recruiting
Not Applicable

The Effectiveness of Different Pulse Duration of NMES in Patients With Pyramidal Tract-related Spasticity Measured by Neurophysiological Tools

Pyramidal Tract-related SpasticityUpper Motor Neuron Lesion
University of West Attica45 enrolled1 locationNCT07321158
Recruiting
Not Applicable

Impact of rTMS Combined With Neurorehabilitation on Lower Extremity Motor Function and Spasticity in Children With Spastic Diplegic Cerebral Palsy

Cerebral Palsy (CP)Transcranial Magnetic StimilationDiplegic Cerebral Palsy With Spasticity+1 more
Ankara City Hospital Bilkent20 enrolled1 locationNCT07488429
Recruiting
Not Applicable

Upper Limb Nerve Cryoneurolysis is Non Inferior to the Usual Care and Has Therapeutic Add Value in Dealing With Shoulder Pain and Functional Problems Caused by Spasticity and Motor Impairment

Traumatic Brain InjuryStrokeMultiple Sclerosis+5 more
Centre National de Rééducation Fonctionnelle et de Réadaptation50 enrolled1 locationNCT06782464
Recruiting

Spastic Paraplegia - Centers of Excellence Research Network

Neuromuscular DiseasesPrimary Lateral SclerosisHereditary Spastic Paraplegia+6 more
Boston Children's Hospital100 enrolled11 locationsNCT06553976
Recruiting

Registry and Natural History Study for Early Onset Hereditary Spastic Paraplegia

Hereditary Spastic ParaplegiaSPG47SPG50+8 more
Boston Children's Hospital700 enrolled1 locationNCT04712812
Recruiting

Hereditary Spastic Paraplegia Genomic Sequencing Initiative (HSPseq)

Movement DisordersMotor Neuron DiseaseHereditary Spastic Paraplegia+3 more
Boston Children's Hospital200 enrolled1 locationNCT05354622
Recruiting
Not Applicable

Effects of Whole-body Electrical Muscle Stimulation Exercise on Adults With Neuromuscular Disease

Myasthenia GravisAmyotrophic Lateral SclerosisNeuromuscular Diseases (NMD)+15 more
University of Missouri-Columbia50 enrolled1 locationNCT07478172
Recruiting
Not Applicable

The Effect of Targeting the Plantaris Muscle-tendon in Surgical Correction of Ankle Equinus in Children

Idiopathic Toe WalkingTraumatic Brain InjuryStroke+5 more
University of Alberta42 enrolled1 locationNCT07090057
Recruiting

Evaluation of Patients With HAM/TSP

HTLV-I InfectionTropical Spastic Paraparesis
National Institute of Neurological Disorders and Stroke (NINDS)750 enrolled1 locationNCT00001778
Recruiting

Genetic and Physical Study of Childhood Nerve and Muscle Disorders

Muscular DystrophiesMuscle MyopathiesHereditary Spastic Paraplegias+2 more
National Institute of Neurological Disorders and Stroke (NINDS)9,300 enrolled1 locationNCT01568658
Recruiting
Not Applicable

Bimanual Training Versus Unilateral Task Specific Training in Children With Spastic Hemiplegic Cerebral Palsy

Spastic Cerebral Palsy (sCP)
Montiha Azeem46 enrolled1 locationNCT07437274
Recruiting

A Study to Estimate How Often Post-stroke Spasticity Occurs and to Provide a Standard Guideline on the Best Way to Monitor Its Development

Spasticity as Sequela of Stroke
Ipsen1,051 enrolled59 locationsNCT06055725