SPAST Clinical Trials

143 recruitingLast updated: July 25, 2026

There are 143 actively recruiting spast clinical trials across 35 countries. Studies span Not Applicable, Phase 2, Phase 3, Phase 1, Early Phase 1, Phase 4. Top locations include Dallas, Texas, United States, New York, New York, United States, Boston, Massachusetts, United States. Updated daily from ClinicalTrials.gov.


SPAST Trials at a Glance

143 actively recruiting trials for spast are listed on ClinicalTrialsFinder across 6 cities in 35 countries. The largest study group is Not Applicable with 84 trials, with the heaviest enrollment activity in Dallas, New York, and Boston. Lead sponsors running spast studies include Universitaire Ziekenhuizen KU Leuven, Cairo University, and Riphah International University.

Treatments under study

About SPAST Clinical Trials

Looking for clinical trials for SPAST? There are currently 1 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new SPAST trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about SPAST clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 143 trials

Recruiting

Online Study of People Who Have Genetic Changes and Features of Autism: Simons Searchlight

SYNGAP1-Related Intellectual DisabilityDLG4FOXP1+184 more
Simons Searchlight100,000 enrolled2 locationsNCT01238250
Recruiting
Not Applicable

Dorsal Root Electrical Stimulation in Children With Cerebral Palsy

Cerebral PalsyCerebral Palsy (CP)Spasticity+1 more
Martin Piazza15 enrolled1 locationNCT07715006
Recruiting

Evaluation of Patients With HAM/TSP

HTLV-I InfectionTropical Spastic Paraparesis
National Institute of Neurological Disorders and Stroke (NINDS)750 enrolled1 locationNCT00001778
Recruiting
Not Applicable

Effects of Proprioceptive Neuromuscular Facilitation and Task-Oriented Training on Upper Extremity Function in Children With Spastic Diplegic Cerebral Palsy

Cerebral PalsySpastic Diplegia
Ibadat International University, Islamabad63 enrolled1 locationNCT07694804
Recruiting
Phase 1Phase 2

Melpida: Recombinant Adeno-associated Virus (Serotype 9) Encoding a Codon Optimized Human AP4M1 Transgene (hAP4M1opt)

Spasticity, MuscleSpastic ParaplegiaMicrocephaly+3 more
Elpida Therapeutics SPC4 enrolled1 locationNCT05518188
Recruiting
Not Applicable

Effect of Lower Extremity Modified Constraint-induced Movement Therapy on Locomotion in Children With Hemiplegia

Spastic Hemiplegic Cerebral Palsy
Cairo University30 enrolled1 locationNCT07686809
Recruiting
Not Applicable

Comparing Mixed Reality and Physical Therapy to Improve Balance and Coordination in Adolescents With Spastic Diplegic Cerebral Palsy

Cerebral PalsySpastic Diplegic Cerebral Palsy
Ibadat International University, Islamabad40 enrolled1 locationNCT07685327
Recruiting
Not Applicable

Effects of Hand and Arm Bimanual Intensive Therapy Including Lower Extremity in Spastic Cerebral Palsy

Cerebral PalsyCerebral Palsy, Spastic
Lahore University of Biological and Applied Sciences42 enrolled1 locationNCT07253857
Recruiting
Not Applicable

Trial to Test the Effectiveness of Vibrotactile Stimulation for Lower Limb Spasticity

Lower limb spasticity
Weill Medical College of Cornell University25 enrolled1 locationNCT07447934
Recruiting
Phase 2

A Study to Evaluate the Efficacy, Safety and Tolerability of BMS-986368 in Participants With Multiple Sclerosis Spasticity

Multiple Sclerosis Spasticity
Celgene200 enrolled54 locationsNCT06782490
Recruiting
Not Applicable

Impact of rTMS Combined With Neurorehabilitation on Lower Extremity Motor Function and Spasticity in Children With Spastic Diplegic Cerebral Palsy

Cerebral Palsy (CP)Transcranial Magnetic StimilationDiplegic Cerebral Palsy With Spasticity+1 more
Ankara City Hospital Bilkent20 enrolled1 locationNCT07488429
Recruiting
Not Applicable

Robot-assisted Versus Conventional Physical Therapy for Hand in Sub-acute Stroke

Upper-limb motor impairmentStrokeSpastic Hemiplegia
Montiha Azeem30 enrolled1 locationNCT07615569
Recruiting

PREcision MEDicine In Achalasia (PREMEDIA) - Cohort

Type III AchalasiaEGJ Outflow Obstruction With Spastic/Hypercontractile FeaturesJackhammer Esophagus+1 more
Northwestern University200 enrolled13 locationsNCT07293689
Recruiting
Phase 3

PREcision MEDicine In Achalasia (PREMEDIA)

Type I AchalasiaType II AchalasiaEGJ Outflow Obstruction Without Spastic/Hypercontractile Features
Northwestern University372 enrolled13 locationsNCT07293650
Recruiting
Not Applicable

Sensory Walkway and Gait in Children With Diplegic Cerebral Palsy

Spastic Diplegic Cerebral Palsy
Cairo University44 enrolled1 locationNCT07595744
Recruiting

Evaluation of Brain MRI Changes in Cerebral Palsy Patients

Cerebral PalsySpastic DiplegiaSpastic Quadriplegia+1 more
Columbia University30 enrolled1 locationNCT07433647
Recruiting
Not Applicable

Feasibility Nutritional Supplements for Muscle Growth in CP

Spastic Cerebral Palsy
Universitaire Ziekenhuizen KU Leuven5 enrolled1 locationNCT06044168
Recruiting

3D-Microscopic Muscle Architecture in Cerebral Palsy

Spastic Cerebral Palsy
Universitaire Ziekenhuizen KU Leuven130 enrolled1 locationNCT06584851
Recruiting

Genetic and Physical Study of Childhood Nerve and Muscle Disorders

Muscular DystrophiesMuscle MyopathiesHereditary Spastic Paraplegias+2 more
National Institute of Neurological Disorders and Stroke (NINDS)9,300 enrolled1 locationNCT01568658
Recruiting
Phase 1Phase 2

A Study to Assess the Safety and Efficacy of IPN10200 in Adult Participants With Upper Limb Spasticity.

Spasticity
Ipsen240 enrolled81 locationsNCT04752774