SPAST Clinical Trials

134 recruitingLast updated: May 13, 2026

There are 134 actively recruiting spast clinical trials across 35 countries. Studies span Not Applicable, Phase 2, Phase 3, Phase 1, Early Phase 1, Phase 4. Top locations include Dallas, Texas, United States, Boston, Massachusetts, United States, Leuven, Vlaams-Brabant, Belgium. Updated daily from ClinicalTrials.gov.


SPAST Trials at a Glance

134 actively recruiting trials for spast are listed on ClinicalTrialsFinder across 6 cities in 35 countries. The largest study group is Not Applicable with 77 trials, with the heaviest enrollment activity in Dallas, Boston, and Leuven. Lead sponsors running spast studies include Universitaire Ziekenhuizen KU Leuven, Riphah International University, and Cairo University.

Treatments under study

About SPAST Clinical Trials

Looking for clinical trials for SPAST? There are currently 1 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new SPAST trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about SPAST clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 134 trials

Recruiting
Phase 2

A Study to Evaluate the Efficacy, Safety and Tolerability of BMS-986368 in Participants With Multiple Sclerosis Spasticity

Multiple Sclerosis Spasticity
Celgene200 enrolled54 locationsNCT06782490
Recruiting

Evaluation of Patients With HAM/TSP

HTLV-I InfectionTropical Spastic Paraparesis
National Institute of Neurological Disorders and Stroke (NINDS)750 enrolled1 locationNCT00001778
Recruiting

3D-Microscopic Muscle Architecture in Cerebral Palsy

Spastic Cerebral Palsy
Universitaire Ziekenhuizen KU Leuven130 enrolled1 locationNCT06584851
Recruiting
Not Applicable

Feasibility Nutritional Supplements for Muscle Growth in CP

Spastic Cerebral Palsy
Universitaire Ziekenhuizen KU Leuven5 enrolled1 locationNCT06044168
Recruiting

Genetic and Physical Study of Childhood Nerve and Muscle Disorders

Muscular DystrophiesMuscle MyopathiesHereditary Spastic Paraplegias+2 more
National Institute of Neurological Disorders and Stroke (NINDS)9,300 enrolled1 locationNCT01568658
Recruiting
Phase 1Phase 2

A Study to Assess the Safety and Efficacy of IPN10200 in Adult Participants With Upper Limb Spasticity.

Spasticity
Ipsen240 enrolled81 locationsNCT04752774
Recruiting
Not Applicable

tSCS in Children and Young People With HCP

Cerebral Palsy Spastic Hemiplegic
University of Leeds18 enrolled1 locationNCT07247812
Recruiting
Not Applicable

Pilot Study on Muscle, Tendon, and Neural Changes Post-Botulinum Toxin Injections in Post-stroke Spastic Equinovarus

StrokeSpasticityEquinovarus Foot
Universitaire Ziekenhuizen KU Leuven12 enrolled1 locationNCT06767631
Recruiting

Botulinum Neurotoxin for Children With CP: a Delicate Balance Between Clinical Benefits and Muscular Harm

Spastic Cerebral Palsy (sCP)
Universitaire Ziekenhuizen KU Leuven51 enrolled1 locationNCT06991725
Recruiting

Muscle-tendon Pathology and Metabolic Dysregulation in CP

Cerebral Palsy, Spastic
University of Graz50 enrolled1 locationNCT06330922
Recruiting
Not Applicable

Neuromodulation to Enhance Motor Function in HSP

Hereditary Spastic Paraplegia
Rahul Sachdeva15 enrolled1 locationNCT07417943
Recruiting
Phase 3

Phase 3 Efficacy Study With Concurrent Control of IT MELPIDA in SPG50.Concurrent Controls.

Hereditary Spastic Paraplegia Type 50
Elpida Therapeutics SPC24 enrolled2 locationsNCT06692712
Recruiting
Not Applicable

Cryoneurolysis for Spasticity Treatment: Long-term Clinical Outcomes and Mechanisms in the Central Nervous System

Spasticity as Sequela of Stroke
Sue Peters25 enrolled1 locationNCT06958289
Recruiting
Not Applicable

A Motor Learning Intervention to Target Walking Performance in Ambulant Children With Cerebral Palsy

Cerebral PalsyWalking, DifficultyHemiplegic cerebral palsy+1 more
Royal College of Surgeons, Ireland14 enrolled1 locationNCT06454656
Recruiting
Not Applicable

Study to Assess the Efficacy and Safety of Iovera®° System in Subjects With Upper Extremity Spasticity

Spasticity, Cerebral or Spinal Condition
Pacira Pharmaceuticals, Inc132 enrolled18 locationsNCT06340451
Recruiting
Not Applicable

Does ESWT With BoNTA Treatment Improve Outcomes When Compared to Standard Management for Upper Limb Spasticity Patient.

Spasticity, Muscle
University of Alberta40 enrolled1 locationNCT05226637
Recruiting
Not Applicable

iCorMicA - Stratified Medicine in Angina

Coronary Artery DiseaseCoronary Microvascular Dysfunction (CMD)Angina, Stable+7 more
NHS Greater Glasgow and Clyde1,500 enrolled39 locationsNCT04674449
Recruiting
Not Applicable

Spinal Cord Stimulation for Children With Cerebral Palsy

Cerebral PalsySpasticity
Martin Piazza30 enrolled1 locationNCT07516067
Recruiting

Classification of Upper and Lower Limb Spasticity Patterns and Their Impact on Quality of Life in Patients With Multiple Sclerosis

Multiple SclerosisSpasticitySpasticity With Multiple Sclerosis
Marmara University75 enrolled1 locationNCT07466823
Recruiting
Phase 3

A Study on Recombinant Botulinum Toxin Type A (YY001) for Injection in Multiple Treatments of Adult Upper Limb Spasticity

Upper Limb Spasticity
Chongqing Claruvis Pharmaceutical Co., Ltd.300 enrolled16 locationsNCT07478822