Surgical Pain Clinical Trials

23 recruitingLast updated: May 9, 2026

There are 23 actively recruiting surgical pain clinical trials across 14 countries. Studies span Not Applicable, Phase 2, Phase 3, Phase 4. Top locations include Boston, Massachusetts, United States, Arnhem, Netherlands, Barcelona, Catalonia, Spain. Updated daily from ClinicalTrials.gov.


Surgical Pain Trials at a Glance

23 actively recruiting trials for surgical pain are listed on ClinicalTrialsFinder across 6 cities in 14 countries. The largest study group is Not Applicable with 10 trials, with the heaviest enrollment activity in Boston, Arnhem, and Barcelona. Lead sponsors running surgical pain studies include Cairo University, Centre Hospitalier Universitaire, Amiens, and Brigham and Women's Hospital.

Browse surgical pain trials by phase

Treatments under study

About Surgical Pain Clinical Trials

Looking for clinical trials for Surgical Pain? There are currently 1 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Surgical Pain trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Surgical Pain clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 23 trials

Recruiting
Not Applicable

Surgical COrncerns and Psychological Evaluation of Patients Undergoing Elective Surgery

Elective surgeryAnxietyChronic post-surgical pain
University Hospital, Antwerp30 enrolled1 locationNCT07158684
Recruiting
Not Applicable

Yoga for Persistent Post-Surgical Pain (PPSP)

Persistent Post-surgical Pain
Brigham and Women's Hospital50 enrolled1 locationNCT06949007
Recruiting
Not Applicable

Intertransverse Process Block to Improve Quality of Recovery and Pain Management in Adult Cardiac Surgical Patients

Chronic Postsurgical Pain
Chinese University of Hong Kong96 enrolled1 locationNCT06946290
Recruiting
Not Applicable

Ultrasound-Guided SPSIP Versus ESPB for Postoperative Pain After Modified Radical Mastectomy

Breast CancerPostoperative PainAcute Post-surgical Pain
Cairo University50 enrolled1 locationNCT07446868
Recruiting

Investigate and Predict Aortic & Thoracic Surgery Persistenet Postsurgical Pain

Persistent Postsurgical Pain
Queen Mary University of London60 enrolled1 locationNCT05369130
Recruiting
Not Applicable

Acute Preoperative Pain and Chronic Post-surgical Pain in Emergency Surgery

Emergency surgeryPostoperative PainRisk Factors+3 more
Centre Hospitalier Universitaire, Amiens693 enrolled1 locationNCT06555107
Recruiting
Phase 4

Reducing Perioperative Oxidative Stress to Prevent Postoperative Chronic Pain Following Total Knee Arthroplasty

Osteoarthritis, KneeTotal Knee ArthroplastyChronic Postsurgical Pain
Vanderbilt University Medical Center148 enrolled1 locationNCT06083480
Recruiting
Phase 3

Multiprofen-CC™ to Reduce Pain After Total Knee Arthroplasty

postsurgical pain
KAZM Pharmaceuticals Inc.288 enrolled2 locationsNCT06202989
Recruiting
Not Applicable

Radiofrequency Ablation for the Treatment of Post-knee Arthroplasty Chronic Pain.

Chronic Knee PainChronic post-surgical painChronic post operative pain
Consorci Sanitari de l'Alt Penedès i Garraf86 enrolled1 locationNCT05920382
Recruiting
Phase 2

A Study on TLC590 for Managing Postsurgical Pain

Postsurgical Pain Management
TLC Biopharmaceuticals, Inc.120 enrolled2 locationsNCT06574269
Recruiting
Not Applicable

Psychophysical and Neural Mechanisms Contributing to Chronic Post-Surgical Pain in Adolescents and Adults

Chronic post-surgical pain
Massachusetts General Hospital110 enrolled1 locationNCT05304286
Recruiting
Not Applicable

Uncovering the Mechanism of Pain Relief by Peripheral Transcutaneous Magnetic Stimulation

Post-Surgical Pain, ChronicPost-traumatic Pain, Chronic
Florida International University50 enrolled1 locationNCT07199361
Recruiting

Chronic Postsurgical Pain

Cerebral PalsyChronic post-surgical pain
Chantel Burkitt500 enrolled2 locationsNCT05764681
Recruiting
Phase 4

Different Dose Esketamine and Dexmedetomidine for Supplemental Analgesia and Longterm Outcomes

EsketamineDexmedetomidinepostoperative analgesia+2 more
Peking University First Hospital312 enrolled1 locationNCT06087510
Recruiting
Phase 2Phase 3

Dinalbuphine Ester (Naldebain) for Pain Management After Cesarean Section

postsurgical painCesarean SectionChronic post-surgical pain
Dalin Tzu Chi General Hospital120 enrolled1 locationNCT06344169
Recruiting
Not Applicable

HONEY for the Treatment of POst-Tonsillectomy Pain

Post-surgical painAnalgesia
East and North Hertfordshire NHS Trust100 enrolled1 locationNCT06275698
Recruiting
Phase 2

Sustained Release Lidocaine for the Treatment of Postoperative Pain

postsurgical painPostoperative Pain
University of British Columbia120 enrolled2 locationsNCT05193227
Recruiting

The Follow-up After Shorter Tapes Study. Effectiveness and Safety of Shorter Trans-obturator Tapes.

postsurgical painStress Urinary IncontinenceFollow-Up Studies
University Hospital, Akershus750 enrolled1 locationNCT06731985
Recruiting

Chronic Postsurgical Pain: Multivariate Prediction Model

Post-surgical painPost Operative PainPostoperative Pain, Chronic
Societa Italiana Anestesia Analgesia Rianimazione e Terapia Intensiva1,500 enrolled1 locationNCT06417528
Recruiting
Not Applicable

Comparison of Conventional and Cooled Radiofrequency of the Genicular Nerves in Patients With Chronic Knee Pain

Knee OsteoarthritisChronic Knee PainPersistent Postsurgical Pain
Ziekenhuis Oost-Limburg400 enrolled15 locationsNCT05407610