ActivePhase 3ACTRN12605000009617

The DECRA trial

Multi-centre randomised trial to evaluate the effect of early decompressive craniectomy on neurological function in patients with severe traumatic brain injury

Sponsor

National Trauma Research Institute, The Alfred

Enrollment

165 participants

Start Date

Aug 25, 2003

Study Type

Interventional

Conditions

Severe diffuse traumatic brain injury with refractory intracranial hypertension

Summary

In adults with severe diffuse traumatic brain injury and refractory intracranial hypertension, early bifrontotemporoparietal decompressive craniectomy decreased intracranial pressure and the length of stay in the ICU but was associated with more unfavorable outcomes.

Eligibility

Sex: Both males and femalesMin Age: 15 YearssMax Age: 60 Yearss

Inclusion Criteria1

First 72 hours from time of injury-Severe diffuse traumatic brain injury-ICP monitor in-situ -Refractory intracranial hypertension

Exclusion Criteria1

Mass lesion>3cm-EDH/SDH>0.5cm or requiring evacuation-Spinal cord injury-Penetrating brain injury-Cardiac arrest at scene-Fixed dilated pupils and GCS=3-Neurosurgery contraindicated-No chance of survival after review of CT brain scan and clinical findings (Neurosurgeon decision).

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Interventions

Early decompressive craniectomy

Locations(1)

ACT,NSW,QLD,SA,WA, Australia

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ACTRN12605000009617