ActivePhase 3ACTRN12605000009617

The DECRA trial

Multi-centre randomised trial to evaluate the effect of early decompressive craniectomy on neurological function in patients with severe traumatic brain injury

Sponsor

National Trauma Research Institute, The Alfred

Enrollment

165 participants

Start Date

Aug 25, 2003

Study Type

Interventional

Conditions

Severe diffuse traumatic brain injury with refractory intracranial hypertension

Summary

In adults with severe diffuse traumatic brain injury and refractory intracranial hypertension, early bifrontotemporoparietal decompressive craniectomy decreased intracranial pressure and the length of stay in the ICU but was associated with more unfavorable outcomes.

Eligibility

Sex: Both males and femalesMin Age: 15 YearssMax Age: 60 Yearss

Plain Language Summary

Simplified for easier understanding

The DECRA trial studies whether removing part of the skull (decompressive craniectomy) can improve outcomes for people with severe traumatic brain injury when other treatments have not controlled brain swelling. People aged 15 to 60 who have had a severe diffuse brain injury within the past 72 hours may be eligible.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

Early decompressive craniectomy

Locations(1)

ACT,NSW,QLD,SA,WA, Australia

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ACTRN12605000009617