ActivePhase 3ACTRN12605000061639

Randomised controlled trial of maintenance fluids in paediatric intensive care.

Randomised controlled trial of maintenance fluids in paediatric intensive care: effect on plasma sodium concentration.

Sponsor

Women's and Children's Hospital Adelaide. Not sponsored financially.

Enrollment

48 participants

Start Date

Mar 14, 2005

Study Type

Interventional

Conditions

Children admitted to paediatric intensive care (PICU)

Eligibility

Sex: Both males and femalesMin Age: 28 Dayss

Inclusion Criteria1

Children over 28 days old admitted to PICU who would normally receive IV maintenance fluids for at least 12 hours.

Exclusion Criteria1

Dysnatraemia (sodium <135mmol/L or >145 mmol/L), glucose <3.5 mmol/L, contra-indications to maintenance fluids (full list available from the chief investigator, includes renal failure, diabetic ketoacidosis, gastroenteritis, raised intra-cranial pressure), previous enrolment, blood tests or IV fluids not indicated.

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Interventions

Main study: randomised to either traditional maintenance fluid rate or 2/3 this rate as either 0.9% saline or 4% dextrose 0.18% saline for 12 to 24 hours (factorial design). Secondary study: randomis

Main study: randomised to either traditional maintenance fluid rate or 2/3 this rate as either 0.9% saline or 4% dextrose 0.18% saline for 12 to 24 hours (factorial design). Secondary study: randomised to 2/3 traditional maintenance rate as either 0.9% saline or 4% dextrose 0.18% saline for 12 to 24 hours.

Locations(1)

Australia

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ACTRN12605000061639