A prospective, randomized, double-blind, placebo-controlled trial of multimodal intraoperative analgesia for laparoscopic excision of endometriosis.

This study looks at whether using a combination of pain relief methods during laparoscopic (keyhole) surgery to remove endometriosis reduces pain, nausea, and the need for strong pain medications afterwards. Endometriosis is a condition where tissue similar to the lining of the uterus grows outside it, causing pain. The combination of local anaesthetic, anti-inflammatory suppositories, and paracetamol is tested in this study. You may be eligible if: - You are a woman between 18 and 45 years old - You have consented to laparoscopic (keyhole) surgery to investigate and remove suspected endometriosis - You can understand and answer questions about pain, nausea, and vomiting You may NOT be eligible if: - You have not given informed consent - You have an allergy to local anaesthetics or to paracetamol - You have a reason you cannot use rectal anti-inflammatory suppositories (Voltaren) - You are pregnant - You are currently on prescribed codeine or opioid pain medications - You have an active or recurring pelvic inflammatory disease - You have a suspected gynaecological cancer - You are planning a laparoscopic hysterectomy - You have difficulty understanding written or spoken English Talk to your doctor about whether this trial might be right for you.