The GABA Study
Single-dose Pregabalin in Postoperative Pain Relief after Minor Gynaecological Surgery
Professor Michael Paech
90 participants
Aug 8, 2005
Interventional
Conditions
Summary
Women undergoing D&C surgery often experience pain afterwards between 2 and 7 on a scale of 1-10. This pain is intially due to surgical trauma but may continue because of resulting inflammation. If the ongoing cycle of inflammation is reduced pain may be less. Pregabalin is a treatment for seizure disorders. It also has pain relieving and calming properties. It can reduce local tissue inflammation and the release of pain mediators. Therefore pregabalin given preoperatively may reduce postoperative pain.
Eligibility
Inclusion Criteria1
- Undergoing minor gynaecological surgery on uterus/cervix without skin or mucosal incision, i.e. D&C +/- Hysteroscopy. ASA 1 or 2.
Exclusion Criteria1
- Allergy to pregabalin.History of chronic pelvic pain.Receiving preoperative misoprostol.Currently taking opioids or other forms of pain relief, sedatives or anticonvulsants.Preoperative history of dizziness or severe headaches.Petient request for sedative/anxiolytic premedication.
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Interventions
Single-dose pregabalin 100 mg administered 1-2 hours pre-operatively, effect on postoperative pain assessed.
Locations(1)
View Full Details on ANZCTR
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ACTRN12605000223639