RecruitingPhase 4ACTRN12605000223639

The GABA Study

Single-dose Pregabalin in Postoperative Pain Relief after Minor Gynaecological Surgery


Sponsor

Professor Michael Paech

Enrollment

90 participants

Start Date

Aug 8, 2005

Study Type

Interventional

Conditions

Summary

Women undergoing D&C surgery often experience pain afterwards between 2 and 7 on a scale of 1-10. This pain is intially due to surgical trauma but may continue because of resulting inflammation. If the ongoing cycle of inflammation is reduced pain may be less. Pregabalin is a treatment for seizure disorders. It also has pain relieving and calming properties. It can reduce local tissue inflammation and the release of pain mediators. Therefore pregabalin given preoperatively may reduce postoperative pain.


Eligibility

Sex: Females

Plain Language Summary

Simplified for easier understanding

This study, called the GABA Study, looks at whether a medication called pregabalin — taken before minor gynaecological surgery (such as a D&C or hysteroscopy) — can reduce pain afterwards. Pregabalin is normally used to treat seizures and nerve pain, but it also has calming and anti-inflammatory properties. Researchers think that taking it before surgery may help reduce post-procedure pain. You may be eligible if: - You are a woman scheduled for minor gynaecological surgery on the uterus or cervix (such as D&C, with or without hysteroscopy) - Your general health status is ASA class 1 or 2 (generally healthy or with mild health conditions) You may NOT be eligible if: - You have an allergy to pregabalin - You have a history of chronic pelvic pain - You are taking the cervical softening drug misoprostol before surgery - You are currently taking opioids, other pain medications, sedatives, or anti-seizure medications - You have a history of dizziness or severe headaches - You have requested a sedative or calming medication before surgery Talk to your doctor about whether this trial might be right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

Single-dose pregabalin 100 mg administered 1-2 hours pre-operatively, effect on postoperative pain assessed.

Single-dose pregabalin 100 mg administered 1-2 hours pre-operatively, effect on postoperative pain assessed.


Locations(1)

Australia

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ACTRN12605000223639