Obstructive Sleep Apnoea and Cardiovascular Disease
The effects of short term hypoxia on arterial stiffness in subjects with obstructive sleep apnoea.
NHMRC
20 participants
Apr 16, 2003
Interventional
Conditions
Eligibility
Inclusion Criteria1
- Severe OSA based on polysomnography (Respiratory Disturbance Index (RDI) 25 ).
Exclusion Criteria1
- History of other cardiovascular or respiratory disease including hypertension, hypercholesterolemia, ischaemic heart disease or diabetesSmoker Treatment with cardiovascular or respiratory medication.
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Interventions
Subjects will be exposed to short term hypoxia aiming for a target saturation of 80% while haemodynamic and ventilatory parameters are measured. They will breathe through a mouthpiece connected to special equipment which delivers different gas mixtures and enables the delivery of the hypoxic exposure. Heart rate, blood pressure, arterial stiffness ( via pulse wave analysis), and peripheral vasoconstriction (via peripheral arterial tonometry PAT) will be measured. Initially there will be a 10 minute baseline period followed by the 20 minute period of hypoxia and then a 10 minute recovery period. A proportion of subjects will then be studied after being commenced on treatment with continuous positive airway pressure (CPAP).
Locations(1)
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ACTRN12605000271606