CompletedPhase 4ACTRN12605000274673
The effect of calcium supplementation on lipids and bone density in men.
The effect of calcium supplementation on serum lipids and bone density in normal men.
Sponsor
Professor I Reid
Enrollment
300 participants
Start Date
Apr 15, 2004
Study Type
Interventional
Conditions
Summary
This is a 2 year study designed to determine the effect 1g of calcium supplements daily on lipids and bone density in men.
Eligibility
Sex: MalesMin Age: 40 Yearss
Inclusion Criteria1
- Males, Age > 40 years, Life expectancy > 5 years.
Exclusion Criteria1
- Coronary heart disease, Diabetes, 5 yr predicted cardiovascular risk of > 15%, Renal impairment (serum creatinine > 0.2mmol/l), Untreated hypo- or hyperthyroidism Active liver disease Serum 25-hydroxyvitamin D < 25 nmol/l Concurrent major systemic disease, including malignancy, Metabolic bone disease, Current treatment for hyperlipidaemia or osteoporosis, Regular use of testosterone replacement therapy within the previous 1 year, Regular use of anabolic steroid preparations in the previous 1 year, Treatment with bisphosphonates in the previous 1 year, Treatment with glucocorticoid drugs in the previous year, Lumbar spine bone density < mean-2.0 SD for age-appropriate data (ie: Z score < -2).
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Interventions
Daily 600mg calcium (as the citrate) or 1200mg calcium (as the citrate) over 2 years.
Daily 600mg calcium (as the citrate) or 1200mg calcium (as the citrate) over 2 years.
Locations(1)
View Full Details on ANZCTR
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ACTRN12605000274673