RecruitingPhase 3ACTRN12605000280606

Isocapnic intermittent hypoxia and endothelial dysfunction

The effects of nitric oxide synthase inhibition on arterial stiffness during short term hypoxic exposure in healthy men

Sponsor

NHMRC

Enrollment

10 participants

Start Date

May 15, 2003

Study Type

Interventional

Conditions

Healthy control subjects

Eligibility

Sex: Males

Plain Language Summary

Simplified for easier understanding

This study is investigating how low oxygen levels (hypoxia) — similar to what happens during sleep apnoea — affect the blood vessels in healthy men. In this study, participants will breathe air with lower oxygen levels in controlled laboratory conditions. Researchers want to understand how the blood vessels respond to these low oxygen episodes, which could help explain why sleep apnoea increases the risk of heart disease. You may be eligible if: - You are a healthy male - You do not have any known health conditions You may NOT be eligible if: - You have a history of obstructive sleep apnoea - You have any cardiovascular or respiratory disease - You are a smoker - You are taking any medication for heart or breathing conditions Talk to your doctor about whether this trial might be right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

Subjects will be infused with L-N monomethyl arginine (LNMMA) and saline (placebo) in a single blinded randomized design on two separate days to assess the effect of nitric oxide synthase inhibition on arterial stiffness. Initially there will be a 10 minute baseline period. Then the LNMMA or saline will be infused over 5 minutes, after which there will be another 5 minute baseline period. Following this there will be the 20 minute period of hypoxia and then a 10 minute recovery period. During this the subjects will breathe through a mouthpiece connected to special equipment which delivers different gas mixtures and enables the delivery of the hypoxic exposure. Heart rate blood pressure, arterial stiffness ( via pulse wave analysis), and peripheral vasoconstriction (via peripheral arterial tonometry PAT) will be measured.

Locations(1)

Australia

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ACTRN12605000280606