The AustraliaN Trial Investigating Post Operative Deficit, Early extubation and Survival (ANTIPODES)
The prospective randomised controlled ANTIPODES Trial will test whether early extubation following coronary artery graft surgery (CAGS) and the perioperative anaesthetic management that permits early extubation, results in a significant reduction in postoperative cognitive dysfunction in the short and medium term.
Dr. Brendan Silbert
350 participants
Apr 17, 2001
Interventional
Conditions
Eligibility
Plain Language Summary
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Interventions
To test whether early extubation following CAGS results in a significant reduction in the incidence of POCD. Low dose anaesthesia permitting early extubation will consist of routine clinical practice using fentanyl 10 micrograms/kg, propofol as required. High dose fentanyl anaesthesia will consist of routine clinical practice using fentanyl 50 micrograms/kg, propofol as required. Patients will complete a battery of neuropsychological tests preoperatively, and 6 days, 3 months and 12 months postoperatively. Quality of life and depression will be assessed preoperatively and at 3 months and 12 months postoperatively.
Locations(1)
View Full Details on ANZCTR
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ACTRN12605000285651