Analysis of the effect of a 6 week very low calorie diet (VLCD) on patients at high risk of NASH as shown by changes of liver biopsy, liver biochemistry and CT scan.

This study is looking at whether following a very low calorie diet (VLCD) for 6 weeks can improve liver health in people who are at high risk of a serious liver condition called NASH (non-alcoholic steatohepatitis). NASH is caused by fat build-up in the liver and can lead to liver damage over time. Researchers will check whether the diet improves liver test results and reduces fat in the liver using blood tests, CT scans, and in some cases, liver biopsy. You may be eligible if: - You are between 18 and 60 years old - Your body weight is under 150 kg and has been stable for the last 3 months - You have high blood pressure (above 140/90) or are treated for it - You have Type 2 diabetes or a fasting blood sugar above 6.1 mmol/L - You have one or more abnormal liver function test results - You are willing and able to follow the very low calorie diet for 6 weeks You may NOT be eligible if: - You have pancreatitis, advancing kidney disease, or type 1 diabetes - You are pregnant or breastfeeding - You have acute stroke or heart disease - You have porphyria or a serious mental health condition - You are unable to complete the 6-week program Talk to your doctor about whether this trial might be right for you.