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CompletedPhase 3ACTRN12605000299606

Improving intestinal function after surgery

A prospective, randomised, double-blind, controlled trial examining the effects of prostaglandin inhibition on outcomes after intestinal surgery.

Sponsor

Department of Gastrointestinal Surgery, Flinders Medical Centre

Enrollment

200 participants

Start Date

Jan 10, 2003

Study Type

Interventional

Conditions

Cessation of intestinal motor function post gastrointestinal surgery

Eligibility

Sex: Both males and females

Plain Language Summary

Simplified for easier understanding

This study is about improving intestinal function after surgery. It may be open to people. Participants generally need to have patients underoing gastrointestinal surgery that involves intestinal manipulation (chiefly colorectal surgery). no recent history of gastrointestinal ulceration, intolerance to nonsteriodal antiflammatory drugs. creatinine clearance greater than 30 ml/min. no requirement for postoperative ace inhibitors.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

3 study groups; placebo, Diclofenac, Celecoxib given as a preoperative dose and continued until discharge, or 7 days postoperatively. All patients receive Pantoprazole 40 mg daily.

3 study groups; placebo, Diclofenac, Celecoxib given as a preoperative dose and continued until discharge, or 7 days postoperatively. All patients receive Pantoprazole 40 mg daily.

Locations(1)

Australia

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ACTRN12605000299606