Use of ethanol to prevent infection in tunnelled intravenous catheters in haematology patients treated with chemotherapy.
A Prospective double-blind randomised clinical trial of 70% ethanol to prevent luminal microbial colonisation of tunneled catheters and associated catheter related sepsis, in haematology patients treated with chemotherapy.
Canterbury District Health Board
100 participants
Jan 3, 2002
Interventional
Conditions
Eligibility
Inclusion Criteria1
- Consent. Central venous catheter in-situ For chemotherapy requiring an in-patient stay for >5 days. Haematological malignancy / Bone marrow transplant.
Exclusion Criteria1
- Known allergy to ethanol. Out-patient chemotherapy. Positive central line cultures within 7 days of entry into study. Elevated LFTs (>2.5 times above ULN). Known history of alcoholism. Pregnancy/lactating women Febrile above 38.0deg at entry.
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Interventions
To assess the efficacy ans safety of 70% ethanol in preventing luminal colonisation of central venous tunnelled catheters. 70% Ethanol or Heparin/saline will be installed into the lumen of the catheter daily for a duration of 2 hours before being removed. This intervention will continue for the length of the hospital admission for the patient or to a limit of 30 days.
Locations(1)
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ACTRN12605000383662