Bi-level Ventilatory Support during exacerbations of Cystic Fibrosis
Randomised trial of short-term effects of bi-level ventilatory support (BVS) on lung function, gas exchange, exercise capacity, quantitative sputum microbiology and quality of life during an exacerbation of Cystic Fibrosis
SWSAHS
40 participants
Oct 9, 2003
Interventional
Conditions
Summary
This trial was completed recruitment in 2006 and data collection (for time-to-next readmission in 2015. Manuscript was published in the Journal of Physiotherapy 2015, vol 61:142-147.
Eligibility
Inclusion Criteria1
- Acute respiratory exacerbation of Cystic Fibrosis (Fuchs et al 1994) requiring IV antibiotics and admission to hospital; aged over 17 years; FEV1 <60% predicted on admission.
Exclusion Criteria1
- Already using BVS or daytime respiratory failure on admission; problem pneumothoraces; recent massive haemoptysis; pregnant; sputum colonised with burkolderia cepacia; previous participation in this study; admitted for lung transplant work-up.
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Interventions
Patients will be randomised to receive BVS in combination with standard therapy or not throughout a hospital admission for an acute respiratory exacerbation. BVS will be applied when the patient is awake, as an adjunct to chest physiotherapy with a physiotherapist, and for self use for physiotherapy or dyspnoea relief.
Locations(1)
View Full Details on ANZCTR
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ACTRN12605000437662