RecruitingPhase 2ACTRN12605000460606

Phase II study of myeloablative allogeneic transplantation using pegylated G-CSF mobilised peripheral blood stem cells.

A Phase I/II trial to evaluate the effects of allogeneic pegylated G-CSF mobilized stem cells in the treatment of haematological malignancy to inhibit the incidence of GVHD.


Sponsor

A/Prof Geoff Hill

Enrollment

47 participants

Start Date

Jan 19, 2004

Study Type

Interventional

Conditions


Eligibility

Sex: Both males and femalesMax Age: 70 Yearss

Plain Language Summary

Simplified for easier understanding

This study is testing a new approach to bone marrow transplantation (also called stem cell transplantation) for people with blood cancers. The new approach uses a modified form of G-CSF (a drug that stimulates the body to release stem cells into the blood) called pegylated G-CSF to collect stem cells from a matching sibling donor. The transplant is then used to treat the patient's blood cancer. Researchers want to see if this method is safe and effective. You may be eligible if: - You are 70 years old or younger - You have been diagnosed with a blood cancer (such as leukaemia or lymphoma) - You have a brother or sister who is a matching donor (HLA-identical sibling) - Your general health status is good enough for transplant (ECOG performance status 0–2) - Your donor sibling is fit to donate stem cells You may NOT be eligible if: - There are no specific exclusion criteria listed for this study Talk to your doctor about whether this trial might be right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

All donors will receive 12mg of pegylated G-CSF as a single dose sub-cutaneously 4 days prior to stem cell collection.

All donors will receive 12mg of pegylated G-CSF as a single dose sub-cutaneously 4 days prior to stem cell collection.


Locations(1)

Australia

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ACTRN12605000460606