Evaluation of Nitrous Oxide in the Gas Mixture for... (Phase 4) — Recruiting Now

Conditions

The effect of Nitrous Oxide on endothelial function for patients having elective surgery of 2 hour or more duration.

Summary

Patients consenting to the trial will have baseline and day 1 postoperative measurements of their endothelial functioning on one arm. Preoperatively : A blood pressure cuff is inflated on the upper arm and an ultrasound is taken of the blood vessels in the arm as the cuff is deflated. Blood tests are taken for folate, homocysteine, arginine, citrulline, ADMA and nitrate. Intraoperatively : Patients will be randomly allocated to either 70% N2O in oxygen (FiO2 0.3) or oxygen with or without nitrogen (FiO2 0.8-1.0). Postoperatively : Patients will have the ultrasound on the same arm as preoperatively and blood tests will be done again. Half of the patients will have received nitrous oxide for a minimum of 2 hours and the other half only oxygen.

Eligibility

Sex: Both males and femalesMin Age: 18 Yearss

Plain Language Summary

Simplified for easier understanding

This is a clinical study looking at: Evaluation of Nitrous Oxide in the Gas Mixture for Anaesthesia. It may be open to adults aged 18 and older. Key requirements include: Any risk factors for arteriosclerosis (eg. hypertension, diabetes, age >60 yrs, coronary artery disease). 2. Participation typically involves medical assessments and follow-up visits as part of the research.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interventions

Patients consenting to the trial will have baseline and day 1 postoperative measurements of their endothelial functioning on one arm. Preoperatively : A blood pressure cuff is inflated on the uppe

Patients consenting to the trial will have baseline and day 1 postoperative measurements of their endothelial functioning on one arm. Preoperatively : A blood pressure cuff is inflated on the upper arm and an ultrasound is taken of the blood vessels in the arm as the cuff is deflated. Blood tests are taken for folate, homocysteine, arginine, citrulline, ADMA and nitrate. Intraoperatively : Patients will be randomly allocated to either 70% N2O in oxygen (FiO2 0.3) or oxygen with or without nitrogen (FiO2 0.8-1.0). Postoperatively : Patients will have the ultrasound on the same arm as preoperatively and blood tests will be done again. Half of the patients will have received nitrous oxide for a minimum of 2 hours and the other half only oxygen.

Locations(1)

Australia