CompletedPhase 3Phase 4ACTRN12605000556640
Seroquel compared to Risperidone in the treatment of psychotic disorders adolescents.
Randomised controlled clinical trial of the efficacy and tolerability of Seroquel compared to Risperidone in the treatment of psychotic disorders among 15-18 year old adolescents.
Sponsor
Dr Harith Swadi
Enrollment
60 participants
Start Date
Jun 1, 2003
Study Type
Interventional
Conditions
Summary
The purpose of this study is to determine if treatment with quetiapine will improve young patients psychosis.
Eligibility
Sex: Both males and femalesMax Age: 19 Yearss
Inclusion Criteria1
- Provision of written informed consent. Young people under the age of 19 years admitted to the Youth Inpatient Unit YIU) with a psychotic disorder according to DSM-IV criteria.Subjects must have a chronic or intermittent psychosis with a documented clinical diagnosis of: Schizophrenia, Schizophreniform Disorder, Schizoaffective Disorder, Major Depressive Disorder with psychotic features, or Bipolar I Disorder according to the criteria of DSM IV [18].
Exclusion Criteria1
- Patients with alcohol or substance dependence not in full remission. Previous and successful treatment with Quetiapine or Risperidone.History of non-response to atypicals.Patients who have taken Clozapine within the previous 60 days.A positive test for pregnancy.Sexually active females who are not on a medically validated contraceptive e.g. double barrier, oral contraceptives, DepoProvera.Any clinical significant medical condition that could affect required evaluation or increase the risk of adverse affects with treatment.
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Interventions
Quetiapine fumarate (titrate to between 400 and 800mg)
Risperidone (titrated to between 4-6mg)
Quetiapine fumarate (titrate to between 400 and 800mg) Risperidone (titrated to between 4-6mg)
Locations(1)
View Full Details on ANZCTR
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ACTRN12605000556640