CompletedPhase 4ACTRN12605000557639

The ATACAS Trial: Aspirin and Tranexamic Acid for Coronary Artery Surgery Trial

A prospective, randomised, double blind, factorial trial testing whether aspirin, tranexamic acid, or both, can reduce mortality and/or major morbidity after elective coronary artery surgery.

Sponsor

The Alfred Hospital

Enrollment

4,600 participants

Start Date

Mar 17, 2006

Study Type

Interventional

Conditions

Patient undergoing elective CABG surgery for any reason, who are at an increased risk of major complications due to their age, cardiac function, comorbidity, or previous cardiac surgery.

Summary

A total of 4,400 people having coronary artery bypass graft surgery will participate in this project. Whilst surgery offers benefit to the majority ofpatients, a small proportion have serious complications (such as heart attack, stroke, infection or even death). Each of these can have a marked effect on quality of life. The purpose of this project is to study the effects of two medications, each of which may reduce complications associated with your heart surgery. The two drugs being tested are aspirin and tranexamic acid (TA). Aspirin and / or TA may protect against some of these complications.

Eligibility

Sex: Both males and femalesMin Age: 18 Yearss

Plain Language Summary

Simplified for easier understanding

This is a clinical study looking at: The ATACAS Trial: Aspirin and Tranexamic Acid for Coronary Artery Surgery Trial. It may be open to adults aged 18 and older. Key requirements include: Written, informed consent. 2. Participation typically involves medical assessments and follow-up visits as part of the research.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

Cessation of the aspirin arm of the study recommended by the steering committee and endorsed by the data saftey monitoring committee. The ATACAS Trial has been established to answer a clinically impo

Cessation of the aspirin arm of the study recommended by the steering committee and endorsed by the data saftey monitoring committee. The ATACAS Trial has been established to answer a clinically important question: Should tranexamic acid (TA), be used in people having heart bypass surgery? Patients will now be randomly allocated to one of 2 treatment groups: Tranexamic Acid; Placebo

Locations(4)

Ontario, Quebec, Canada

England, United Kingdom

Hong Kong, Hong Kong

Auckland, New Zealand

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ACTRN12605000557639