RecruitingACTRN12605000563662

Bowel recovery after colorectal surgery: A comparison of patient contolled analgesia with tramadol versus morphine

Sponsor

Stephan Schug

Enrollment

36 participants

Start Date

Oct 12, 2001

Study Type

Interventional

Conditions

Return of normal gastrointestinal function

Eligibility

Sex: Both males and females

Inclusion Criteria1

ASA 1-3, elective colorectal surgery.

Exclusion Criteria1

Patients with known gastrointestinal tract disorders, previous abdominal radiotherapy, clinically relevant liver or renal impairment, chronic pre-op opiod use, patients unsuitable for PCA, planned epidural analgesia.

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Interventions

Post-operative analgesia via PCA containing either tramadol 600mg in 30mls n.saline or morphine 60mg in 30mls n. saline. PCA commenced in recovery and programmed to deliver an initial loading dose of

Post-operative analgesia via PCA containing either tramadol 600mg in 30mls n.saline or morphine 60mg in 30mls n. saline. PCA commenced in recovery and programmed to deliver an initial loading dose of 0.1ml study drug/kg body weight. Patient demand boluses then set at 0.5ml study drug with 5minute lockout and no dose limit. Bolus dose can be inreased to 1ml if analgesia inadequate. If increase in dose remains inadequate then patient will be withdrawn from trial and receive alternative analgesia as per Acute Pain Service protocol. Study duration < 1 week for each subject. Computer programme randomisation by pharmacy.

Locations(1)

Australia

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ACTRN12605000563662