RecruitingACTRN12605000563662

Bowel recovery after colorectal surgery: A comparison of patient contolled analgesia with tramadol versus morphine


Sponsor

Stephan Schug

Enrollment

36 participants

Start Date

Oct 12, 2001

Study Type

Interventional

Conditions


Eligibility

Sex: Both males and females

Plain Language Summary

Simplified for easier understanding

This study compares two pain medications — tramadol and morphine — given through a patient-controlled analgesia (PCA) pump after bowel surgery. A PCA pump allows patients to give themselves small doses of pain medication by pressing a button. Researchers want to know whether tramadol leads to a quicker return of normal bowel function compared to morphine, since morphine is known to slow the digestive system. You may be eligible if: - You are having planned (elective) colorectal (bowel) surgery - You have a good to moderate health status (ASA classification 1–3) You may NOT be eligible if: - You have a known gastrointestinal disorder - You have had previous radiation therapy to your abdomen - You have clinically significant liver or kidney problems - You have been taking opioid pain medications long-term before your surgery - You are not suitable for patient-controlled analgesia - You are planned to have an epidural for pain management Talk to your doctor about whether this trial might be right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

Post-operative analgesia via PCA containing either tramadol 600mg in 30mls n.saline or morphine 60mg in 30mls n. saline. PCA commenced in recovery and programmed to deliver an initial loading dose of

Post-operative analgesia via PCA containing either tramadol 600mg in 30mls n.saline or morphine 60mg in 30mls n. saline. PCA commenced in recovery and programmed to deliver an initial loading dose of 0.1ml study drug/kg body weight. Patient demand boluses then set at 0.5ml study drug with 5minute lockout and no dose limit. Bolus dose can be inreased to 1ml if analgesia inadequate. If increase in dose remains inadequate then patient will be withdrawn from trial and receive alternative analgesia as per Acute Pain Service protocol. Study duration < 1 week for each subject. Computer programme randomisation by pharmacy.


Locations(1)

Australia

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ACTRN12605000563662