CompletedPhase 2Phase 3ACTRN12605000579695

Heparin In Total Parenteral Nutrition

Randomised controlled trial of heparin in total parenteral nutrition to reduce the complications of peripherally inserted central venous catheters (long lines) in neonates.


Sponsor

Dr Pita Birch

Enrollment

200 participants

Start Date

Mar 5, 2004

Study Type

Interventional

Conditions

Summary

In this trial we are testing the hypothesis that the addition of low dose heparin to total parenteral nutrition reduces the complications associated with long lines in neonates, particularly long line infections. We are investigating the possible benefits of heparin in improving the delivery of TPN to sick or premature neonates. In this study half of the babies will have heparin added to their TPN and the other half will have TPN without heparin. No one, except for the pharmacists, will know which babies are having heparin and which ones are not and this makes the trial double blind. At the end of the study we will compare the two groups to see if the babies that have had heparin have had less infections or less complications in general.


Eligibility

Sex: Both males and femalesMin Age: 0 YearssMax Age: 3 Yearss

Plain Language Summary

Simplified for easier understanding

This study tests whether adding heparin (a blood-thinning medicine) to intravenous feeding solutions can help prevent complications like blood clots. It is open to people up to age 3 who are receiving total parenteral nutrition through an IV line. Participants would be monitored for any clotting or line-related complications.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

Randomised double blind controlled trial with Heparin added to the total parenteral nutrition at a concentration of 0.5IU/mL. The intervention continues for as long as the infant is receiving total pa

Randomised double blind controlled trial with Heparin added to the total parenteral nutrition at a concentration of 0.5IU/mL. The intervention continues for as long as the infant is receiving total parenteral nutrition or a predetermined end site is reached, such as confirmed central line infection.


Locations(1)

New Zealand

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ACTRN12605000579695