CompletedPhase 3ACTRN12605000600640
The effect of parecoxib on post craniotomy analgesia.
A prospective randomised controlled, double-blind study of Parecoxib versus placebo for postoperative analgesia following craniotomy surgery.
Sponsor
Department of Anaesthesia, St Vincent's Hospital Melbourne
Enrollment
82 participants
Start Date
Oct 6, 2005
Study Type
Interventional
Conditions
Eligibility
Sex: Both males and femalesMin Age: 18 Yearss
Inclusion Criteria1
- Alert and orientated, patients presenting for elective craniotomy.
Exclusion Criteria1
- Allergy or contraindication to NSAID's, sulphonamides or morphine.Combination ACE inhibitors and diuretics OR either an ACE inhibitor or diuretic if over 70 years oldAsthma if aggrevated by NSAID's or never taken NSAID'sSignificamt peptic ulcer diseaseRenal impairmentChronic pain conditions or taking oral morphine or NSAID's taken on day of surgeryNon English speaking or unable to understand Visual Analogue ScoreIschaemic Heart Diseae or Cerebrovascular DiseaseAny preoperative confusion or sedation.
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Interventions
This prospective randomised controlled, double-blind study has been designed to examine if a single dose of Parecoxib 40mg decreases postoperative pain and morphine requirements for 24 hours following
This prospective randomised controlled, double-blind study has been designed to examine if a single dose of Parecoxib 40mg decreases postoperative pain and morphine requirements for 24 hours following craniotomy surgery.
Locations(1)
View Full Details on ANZCTR
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ACTRN12605000600640