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CompletedPhase 3Phase 4ACTRN12605000639628

Effect of preoperative atenolol on morality and cardiovascular morbidity after non-cardiac surgery.

A prospective, double-blind randomised control study comparing the effect of atenolol versus placebo on mortality and cardiovascular morbidity in patients undergoing non-cardiac surgery.

Sponsor

Department of Anaesthesia, St Vincent's Hospital, Melbourne

Enrollment

200 participants

Start Date

Dec 1, 2000

Study Type

Interventional

Conditions

Patients undergoing major non-cardiac surgery.

Eligibility

Sex: Both males and females

Plain Language Summary

Simplified for easier understanding

This study tests whether taking atenolol (a beta-blocker heart medication) before surgery can reduce the risk of death and heart complications. It is open to adults who are scheduled for major surgery. Participants would take the medication before their operation and be monitored for cardiovascular events afterward.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

Double-blind, randomised control trial comparing atenolol or placebo given preoperatively and for 7 days postoperatively. Patients are telephoned at 3 months, 6 months, 12 months and 2 years postopera

Double-blind, randomised control trial comparing atenolol or placebo given preoperatively and for 7 days postoperatively. Patients are telephoned at 3 months, 6 months, 12 months and 2 years postoperatively to follow up on mortality and cardiovascular morbidity.

Locations(1)

Australia

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ACTRN12605000639628