CompletedPhase 3Phase 4ACTRN12605000639628
Effect of preoperative atenolol on morality and cardiovascular morbidity after non-cardiac surgery.
A prospective, double-blind randomised control study comparing the effect of atenolol versus placebo on mortality and cardiovascular morbidity in patients undergoing non-cardiac surgery.
Sponsor
Department of Anaesthesia, St Vincent's Hospital, Melbourne
Enrollment
200 participants
Start Date
Dec 1, 2000
Study Type
Interventional
Conditions
Eligibility
Sex: Both males and females
Inclusion Criteria1
- Any patient undergoing major surgery under general anaesthesia who has at least 2 of the following risk factors for coronary artery disease: diabetes, hypertension, current smoker, cholesterol > 6.2mmol/L.
Exclusion Criteria1
- Known coronary artery disease, long term beta-blocker use, poorly compensated CCF, 3rd degree heart block, inducible bronchospasm (unstable asthma).
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Interventions
Double-blind, randomised control trial comparing atenolol or placebo given preoperatively and for 7 days postoperatively. Patients are telephoned at 3 months, 6 months, 12 months and 2 years postopera
Double-blind, randomised control trial comparing atenolol or placebo given preoperatively and for 7 days postoperatively. Patients are telephoned at 3 months, 6 months, 12 months and 2 years postoperatively to follow up on mortality and cardiovascular morbidity.
Locations(1)
View Full Details on ANZCTR
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ACTRN12605000639628