Treatment of glucocorticoid-induced protein wasting
Impact of growth hormone and androgens on protein metabolism in subjects with polymyalgia rheumatica and inflammatory arthritis
St Vincent's Hospital
24 participants
Jul 1, 2004
Interventional
Conditions
Summary
The primary purpose is to determine whether growth hormone and androgens alter protein metabolism in a way that will reduce protein loss in long-term glucocorticoid users. If so they may be a potential therapy to reduce the skin thinning and muscle weakness that occurs during longterm glucocorticoid use.
Eligibility
Inclusion Criteria1
- Receiving prednisone for > 6 months for polymyalgia rheumatica or inflammatory arthritis.
Exclusion Criteria1
- Diabetes mellitus, cancer, liver or kidney failure.
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Interventions
Two weeks of growth hormone and androgens (testosterone for men, DHEA for women) alone and in combination.
Locations(1)
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ACTRN12605000642684