Seronegatives And Metabolic Abnormalities Protocol 2 (SAMA 002)

This study is looking at how common HIV medicines — specifically Combivir (a combination of two antiretroviral drugs) and Kaletra (a protease inhibitor) — affect cholesterol, blood fats, and blood sugar levels in healthy people who do not have HIV. Understanding these metabolic effects in HIV-negative volunteers helps researchers separate the drug effects from the effects of HIV infection itself. You may be eligible if: - You are 18 years or older - You have tested negative for HIV (both antibody and DNA tests) - You are able to give written consent to take part You may NOT be eligible if: - You have any ongoing physical or mental health condition that would affect your ability to participate (including suspected heart disease) - You have a history of type 1 or type 2 diabetes, or have previously taken diabetes medication - You have used testosterone, oestrogen, growth hormone, oral steroids, or anabolic steroids in the past 6 months - You have a history of alcohol or drug abuse - You have previously used any antiretroviral medicines (including HIV post-exposure treatment) - You have used retinoid-containing compounds in the past 6 months - You are pregnant - You have hepatitis B or hepatitis C infection - You have abnormal blood test results from screening Talk to your doctor about whether this trial might be right for you.