CompletedPhase 3ACTRN12605000768695

COSA Head and Neck Study

A Randomised Comparative Study of Surgery Versus Radiotherapy and Chemotherapy in Patients With Squamous Cell Carcinoma of the Head & Neck

Sponsor

Investigator Initiated. Study Chairman: Dr David Dalley from St Vincents Hospital NSW. Co-ordinating Centre: Clinical Trials Centre, University of Sydney.

Enrollment

270 participants

Start Date

May 1, 1986

Study Type

Interventional

Conditions

Histologically confirmed SCC of oral cavity, pharynx, hypopharynx and larynx.

Eligibility

Sex: Both males and females

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying COSA Head and Neck Study. It is looking for adults who may be eligible to participate. Participation may involve regular medical assessments and follow-up visits. Some medical conditions may prevent you from joining this study.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

Surgery, chemotherapy, radiation therapy. Patients randomised to surgery will proceed to their planned surgery within three weeks of radiotherapy. Post operative radiotherapy may be given if indicate

Surgery, chemotherapy, radiation therapy. Patients randomised to surgery will proceed to their planned surgery within three weeks of radiotherapy. Post operative radiotherapy may be given if indicated. Patients randomised to chemotherapy will be given chemotherapy by intravenous infusion for 4 days, repeated at 21 day intervals. Radiotherapy will commence following the 3rd course of chemotherapy. If required surgery will be conducted at this time. Chemotherapy will then be given simultaneously with the radiotherapy and an additional chemotherapy will be given after the radiotherapy.

Locations(1)

Australia

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ACTRN12605000768695